Embryo Extras Flashcards
1
Q
polydactyly
A
hands with extra fingers: wk 6, upregulation of ZPA
feet with “mirrored, duplicated toes”: wk 7, duplication of ZPA
2
Q
syndactyly
A
downregulation of BMP at wk 8 (fused digits)
same for hands and feet
3
Q
Thalidomide
A
Meromila: missing limbs
Amelia: No limbs
Phocomilia: shortened limbs with hands/feet nearer body
Partial disruption of hox genes
Mainly issue with FGF and AER
wk 4-8 affected
4
Q
prune belly syndrome
A
abnormal migration of hypaxial mesoderm and intermediate mesoderm (gonads)
5
Q
poland syndrome
A
abnormal migration of hypaxial muscle