Embryo 0513FA Flashcards
what gender is the default development?
female -
mesonephric duct must be induced to remain or else parameso will develop
what duct degenerates in female development?
mesonephric duct
paramesonephric develops
what produces testis-determining factor to promote testes development?
SRY gene on Y chromo
where does mullerian inhibitor factor come from?
(AMH) from Sertoli cells.
suppress development of paramesonephric ducts.
what stimulates develop of mesonephric ducts?
increased ANDROGENS from Leydig cells
what develops into male internal structures?
mesonephric (wolffian) ducts become SEED.
Seminal vesicles.
Epididymis.
Ejaculatory duct.
Ductus deferens.
what develops into female internal structures?
paramesonephric (Mullerian) ducts become:
Fallopian tubes.
Uterus.
Upper 1/3 vagina.
where does lower 2/3 vagina come from?
urogenital sinus
bicornuate uterus
incomplete fusion of paramesonephric (Mullerian) ducts.
urinary tract abnormalities.
miscarriage.
no sertoli cell OR lack of AMH
develop both male and female INTERNAL genitalia AND male EXTERNAL genitalia
5alpha reductase deficiency
lack of DHT = male internal genitalia with ambiguous external genitalia until puberty
genital tubercle (estrogen)
glans clitoris.
vestibular bulbs.
genital tubercle (DHT)
glans penis.
corpus cavernosum, spongiosum.
urogenital sinus (estrogen)
greater vestibular glands (of Bartholin).
urethral and paraurethral glands (of Skene).
urogenital sinus (DHT)
bulbourethral glands (of Cowper). prostate gland.
