Elimination and Cellular Regulation Flashcards
- process of urinary and gastrointestinal elimination.
- elimination refers to the secretion and excretion of body wastes from the kidneys and intestines and any alterations from normal of those process.
- Pre-renal, Renal and Post-Renal.
Elimination
dehydrated, problem with electrolytes
Pre-renal
issue with the kidney itself
Renal
kidneys are fine, but something is effecting or blocking
Post renal
Presence of calculi (stones) in the urinary tract
- nephrolithiasis; formation of stones in the kidney
- Urterolithiasis; formation of stones in the ureter
*Obstruction of the urinary tract is the primary problem associated with urolithiasis.
Urinary calculi-Kidney stone
Painful!
Movement of multifaceted crystal that scrapes the ureter as it moves.
-“most painful experience” of the person’s life.
-Most common cause of upper urinary tract obstruction.
flank pain and around the front external genitalia
Kidney stones
-Slow urine flow causing supersaturation with a particular element
-Nucleation-Formation of crystal from liquid.
-Decreased inhibitor substances in the urine that would prevent supersaturation and crystal aggregation.
(People that get them don’t have inhibitor substance)
Formation of stones involve 3 conditions.
2.5 x more common in Males than females between 20-55 yrs of age.
-50% can expect a recurrence
-Family hx
-More common in Asians and whites
More common in dry climates, summer time due to dehydration.
Epidemiology
Calicum oxylate or Calcium Phosphate 75% *most Ca stones
~Struvite/Staghorn 15%; Assoc with UTI caused by Urease-production bacteria such as Proteus.
~Uric Acid 8%; Occur more often in men and associated with Gout; build up of uric acid in joints and gets inflammed
~Cystine 3%; Assoc with genetic defect.
Types of Stones
Urinary stasis, Urinary retention
- immobility
- dehydration/inadequate hydration
- high protein and sodium intake
- Hypercalciuria, Hypercalcemia; calcium in urine or blood
- Hyperparathyroidism
- prolonged steroid intake. Steroids steal Ca from bones
- Genomics; 30 genetic variations assoc with formation of kidney stones.
Contributors to Stone Formation
Acute severe flank pain on the affected side.
-stone obstructs the ureter causing ureteral spasm.
-Pain may radiate to the suprapubic region, groin and external genital.
Often causes a sympathetic response; tachycardia fight or flight response.
N and V. pallor, cool clammy skin
-Stones traumatize ureter causing microscopic to gross hematuria; little/lot of blood
-Complete blockage; hydroureter, Hydronephrosis………..Post renal become renal if not corrected.
Renal Colic
- Mg ammonium phosphate
- Caused by bacteria usually Proteus
- Raising the urinary pH which favors precipitation; alkaline urine, stones to form
- higher incidence in women.
Staghorn/struvite Calculi
Relieve pain by administering drugs
-Eliminate the stones through chemolysis, ESWL (Shock wave), or surgery to remove stones.
-Prevent recurrence by dietary changes, medications and changing the pH of urine.
Fluids, fluids fluids
3 goals of medical management for kidney stones
Administer narcotic analgesics and antispasmodics
- Morphine, Demerol, Dilaudid;(drug of choice for kidney issue)
- NSAID-Toradol (ketorolac)
- hold Nsaid, ASA (aspirin) if surgery is likely bc of increased bleeding risk.
- Apply warm moist packs or offer warm baths.
- Increase fluid intake to at least 3000 ml/day
- Strain all urine-Send stones to lab to find out what type they are. food to avoid, different meds to help. Acidifying or alkaline stone
Nursing Actions for kidney stones
- Urinalysis to assess for hematuria, WBC’s, crystal fragments, Urine pH.
- Chemical analysis of stone-All urine is strained and visible stones or sediment sent for analysis.
- Urine is analyzed for Uric Acid, oxylate excretion.
- KUB; kidney Ureter Bladder Film
- Renal Ultrasound
- CT Scan; gold standard identification
- IV Pyelogram-Dye injected (Beware of dye/seafood allergy) renal; creatinine worsen kidney issues with dye
- Cystoscopy; invasive; bladder; urether
Diagnostic Testing
Minimally Invasive;
- Stenting-enlarges passageway for stone to pass
- Retrograde ureteroscopy, -scope has grasping basket forceps or loops;
- Ureteroscope may be lithotripsy capable; shock waves to the stone.
Surgical Management
Minimally Invasive
Uses sound, laser or dry shock waves to break stone into small fragments. fragmenting kidney stones by using major surgery.
-Shock waves are applied over 30 mins to 2 hours. outside the body.
-Topical cream applied to skin; external, skin can get nasty bruises.
-Bowel prep may be requested.
-Flouroscopic observation for stone destruction during procedure *radiation
-Strain urine to monitor for stone fragments
-Bruising may occur on flank at site of procedure; may be extensive.
Cystine stones usually resistant to ESWL. strong stones
Lithotripsy; Extracorporeal shock wave lithotripsy (ESWL); noninvasive technique
Monitor VS frequently
-Hemorrhage and shock are potential complications; hypovolemic shock
-Bleeding may be retroperitoneal and internal and difficult to detect. c/o low back pain, bleeding H & H lab, stat Cat Scanurine may be bright red initially
bleeding should diminish in 48-72 hours.
Maintain placement and patency of urinary catheters. Anchor catheters securely.
-A kinked or plugged cath may result in hydroureter, hydronephrosis, and kidney damage.
Nursing Care Post-Lithotripsy
Used for large impacted stones.
-open ureterolithotomy-into the ureter (incision is made in the affected ureter to remove a calculus).
Pyelolithotomy-into the kidney pelvis (incision made in the kidney pelvis and removal of a stone).
_Nephrolithotomy; into the kidney; a staghorn calculus that invades the calyces and renal parenchyma maybe required by nephrolithotomy.
*Tubes and drains may be placed.
-Nephrostomy tube, ureteral stent, Penrose, Bulb drain, Foley catheter.
Open Surgical Procedures for Kidney stones
Monitor for bleeding from incision, blood in urine and pain suspicious for internal bleeding. Assess for Shock.
-Maintain fluid intake, monitor I & O’s, strain urine
Post-Op Care:
irrigate q shift with no more than 10 ml of warm, sterile saline.
-Observe for hemorrhage, internally or externally
kidneys are highly vascular.
INR levels
-nephroscope inserted into the kidney pelvis through a small flank incision.
Percutaneous nephrostomy PCN; laser technique
Collaborate with Dietary to give nutrition recommendations based on the type of stone.
- Drink 2.5-3.5 Liters or more a day to provide diluted urine and promote the flow of urine to decrease chance of crystals forming
- encourage activity to prevent bone reabsorption (loss)
Patient Education for kidney stones
A diet excluding foods high in oxalates, do not decrease "Calcium" Foods High in Oxalic Acid `Coffee (instant dry), and Tea brewed `Blackberries, gooseberries, plums (raw) `whole wheat bread `beets, boiled carrots, greenbeans, rhubarb, boiled spinach `cocoa (dry) `ovaltine powder
Oxalate stones and diet
Don’t limit Ca, bc it will be taken from the bone
“kidney stones are not usually caused by dietary calcium. A high-calcium diet binds the oxalate of dietary origin in the gastrointestinal tract and prevents its absorption, thereby reducing urinary oxalate formation”.
Kidney stones
Purine stones: Patients with gout are often put on medication to control gout so may not be placed on low purine diet.
Uric Acid Stones-Diet
Foods high in Purine to avoid:
- Organ meats, liver, kidney, brain, heart
- anchovies, sardines in oil, herring
- sweetbreads
- gravies
high in purine to avoid
Moderate amounts of purine:asparagus, cauliflower, mushrooms, spinach, peas
fowl, lentils, whole grain cereals, beans
moderate in purine to avoid
Oral and Iv fluids reduce the risk of further stone formation and promote urine output.
-After identification of Calculus, med given based on stone kind.
Calcium phospate and or oxalate-Thiazide diuretics, phosphates, calcium binding agents. Struvite; antibiotics
Uric Acid; Potassium Citrate, Allopurinol-akaline urine good for cystine stones, too.
`Cystine-Penicillamine, Sodium becarbonate
Stones and Pharmacology
Age Related;
Nonmalignant enlargement of the prostate gland.
-decreases the outflow of urine by obstructing the urethra causes problems with urination and may compromise kidney function
-Growth may extend up into the bladder and obstruct the outflow of urine
`Not a pre-cursor to prostate cancer!
Preconditions include Age 50 and presence of testes.
-affects 50% of men 51-60, 90% over age 80.
Benign Prostatic Hypertrophy or Hyperplasia BPH
As men age, estrogen levels increase and testosterone levels decrease.
-Elevation of the enzyme 5-alpha-reductase converts testosterone to dihydrotestosterone (DHT) which causes cells to grow. hyperplasia; increase enlarge
-DHT is an androgen hormone.
androgen stimulate the development and maintenance of male sex characteristics.
Etiology of BPH
Age
Fam hx
Race; highest in black and hispanic and lowest in Native Japanese
Diet high in meats and fats
Risk factors for BPH
-Tissue obstructs urethra and bladder outlet
-Urine flow becomes weak
-Straining to empty bladder causes hypertrophy of bladder wall.
-Trabeculation of bladder wall leads to decreased bladder capacity.
-Increased filling pressure causes back up of urine into kidney
-Hydroureters and hydronephrosis and kidney atrophy
-Residual urine becomes alkaline from Stasis.
-Promotes UTI’s and renal and bladder calculi.
-Akaline urine increases stones
Usually patient understands they got it because they lived long enough.
Pathophysiology of BPH-
- Straining to urinate
- post void dribbling
- hesitancy in starting stream
- nocturia
- dysuria
- hematuria
- urgency
- frequency
- incomplete emptying of bladder
- overflow incontinence
- bladder pain.
Clinical Manifestations of BPH
Inability to void (Emergency-What now?) catheter, cudea (bent catheter)
Frequent UTI’s (Labs?) CBC’s-WBC’s
Hematuria (Labs; blood/urinalysis)
Renal and Bladder stones (Calculi)
Renal insufficiency (Labs) BUN, Creatinine
Difficulty or inability to pass urinary catheter
Bladder distention
Bladder Pain
Clinical Manifestations; With higher degree of blockage
Common complications are kidney disorders caused by pressure and backflow of urine.
- Recurrent UTI’s
- Pyleonephritis; inflammation of above the bladder, kidneys, urethers are inflammed
- Sepsis, infected blood
- Secondary renal insufficiency
Complications
Lab tests
- CBC; eval for infection or anemia
- blood urea nitrogen (BUN), Creatinine
- urinalysis
- prostate specific antigen (PSA), baseline is good. not good for prostate cancer diagnosis anymore.
- JM-27; testing for more severe/aggressive form of BPH. More serious bladder damage leading to renal impairment.
Diagnostic Tests (BPH)