Elimination

Question 1

Elimination 2 way?

Answer 1

Excretion
Metabolism

Question 2

Organs aiding in excretion?

Answer 2

Liver, kidney, lung, skin alumanry tract, colon

Question 3

Kidney excretion types?

Answer 3

Passive glomerular filtration
Active tubular excretion
Renal reabsorption

Question 4

Active tubular excretion drugs?

Answer 4

Weak acid: penicillin, frusemide
Weak base : digoxin

Question 5

Renal reabsorption?

Answer 5

Lipid soluble drugs are reabsorbed so it can turn polar by metabolic degradation, conjugation

Question 6

Passive glomerular filtration

Answer 6

For low molecular weight drugs,
Watersoluble
Non bounded
Mannitole example

Question 7

How does change in PH of urine affect excretion?

Answer 7

Alkalization helps eliminate acidic drug like aspirin and barbiturates
Acidification of urine helps eliminate basic drugs like amphetamine ephedrine

Question 8

Enterohepatic circulation

Answer 8

When a drug is absorbed by liver it is conjugated by bile then sent to intestine where bacteria returns the drug to preconjugation form which causes drug tobe reabsorbed by the liver for the cycle tocontinue causes prolongationof drugeffect