Electrolytes: Fluids Flashcards
Hypokalemia= k< ____, symptomatic often below _____
3.5
3.0
Hypokalemia causes
Redistribution from ECF to ICF
Decreased intake
Total K deficit
Hypo K; Redistribution of K from ECF to ICF caused by….
(Some of these are also tx for hyperkalemia)
Alkalosis
Insulin
Beta 2 agonists
Hypercalcemia
Hypomagnesemia
Things to AVOID in Hypokalemia, due to further K depletion in ECF…
Glucose solutions
Hyperventilating (alkalosis)
Rapid correction of acidosis
When replacing K, we should also check and replace ____
Mag
No need to correct chronic Hypokalemia with K < 2.5 mEq/L prior to induction unless _____ therapy
Digitalis
k replacement recommendations for dosage
Less than or equal to 10 mEq/hour
PO Is safest
Hypokalemia effects on NMB drugs?
Hypo k causes weakness- weakness augments NMB
Hypokalemia effects on EKG
Decreased contractility
Hyper-polarized cell (increased gradient)
Flattened t waves
U waves
Increased PRI
Increased QT
atrial of ventricular arrhythmias
Hyperkalemia defined as k > _____, must treat K > ______
Most danger K > ______
5.5
6
7
S/s of acute hyperkalemia
Muscle weakness, especially in legs and respiratory system
Paresthesias (neuro)
Hyperkalemia conduction changes
Prolonged PRI
Peaked T
Loss of P wave
Wide QRS
Vfib/arrest
Etiology Of hyper K
Decreased excretion
ICF to ECF shift
Artificial elevation due to hemolysis of blood sample (double check)
Hypoaldosteronism (aldosterone holds Na and excretes K)
Potassium sparing diuretics (spirolactone)
If your Co2 increases 10 mmhg, the pH will ______ by _____, and the plasma K will increase by ______ mEq/L
Decrease by 0.1
0.5
pH and plasma K are ________ proportional
Inversely proportional
Caution with these medications in renal failure patients
NSAIDS
ACEI
CSA (cyclosporine A)
Administration of succinylcholine is dangerous due to this effect;
Caution in patients with _______
Opens all K pumps and rapidly moves K from intra to extra cellular space, can cause V fib and cardiac arrest
Caution in hyperkalemic patients
If you must use succinylcholine, this may have a protective effect
Hyperventilating prior to injection
Hyperkalemic patients, take precautions to avoid _______ when managing breathing
Hypoventilation, due to increase Co2x decreasing pH, driving more K to ECF
Considering cancelling elective surgery if K>_____.
Do consider if it is acute or chronic. Chronic failure chronic elevation may tolerate
5.5
Always treat K > _____
6
Avoid what induction med in hyperkalemia?
Succinylcholine
Steps to treat hyperkalemia that is life threatening (ekg changes, greater than 6.5, high risk patient)
1) stabilize the heart with Ca (CaCl or calcium gluconate). Consider repeating if EKG changes persist
2) shift K into cells- regular insulin (10-20 units) and glucose (25-50 g)
3) beta 2 agonist inhaled- shift K into cells
4) enhance elimination of K- considering patients volume status-
-low volume- resus with .9 nacl then use loop diuretic it UOP is present
-high volume- move straight to diuretic if UOP is present
No UOP? Dialysis
NMDMR consideration with hyper K?
skeletal weakness suggests decreased dose for muscle relaxants intraop- titrate to effect
IV fluid considerations for hyperkalemia
If using large doses of fluid/ make sure no K.
LR, K is low, but without elimination can build in high doses
Magnesium controls ______ reabsorption in renal tubules
k
______ stabilizes membranes, influences releases of neurotransmitters at the NMJ.
Can inhibit entry of Ca into presynaptic nerve terminals
Endogenous Ca antagonist
Magnesium
This electrolyte is an endogenous NMDA receptor antagonist
Magnesium
Blocks N-methyl receptor, similar to ketamine?
Essential co factor to many enzymatic reactions; DNA and protein synthesis, energy metabolism, glucose utilization, FFA synthesis
Magnesium
Hypomagnesemia= mag < ____ mEq/L
1.5
Hypomagnesemia caused by….
Inadequate intake
Protracted vomiting, diarrhea
Renal insufficiency
Hypomagnesemia signs and symptoms
Skeletal muscle spasms and weakness
CNS irritability
Seizures, hyper-reflexia, confusion, ataxia, cardiac irritability
Hypomagnesemia tx
MgSO4 bolus- 1 go over 15-20 mins
Rate no greater than 1 mEq/min
Hypomagnesemia anesthetic consideration;
Look for associated disturbances; Hypokalemia, hyponatremia, hypocalcemia
Frequently occurs in alcoholic patients
Hypermagnesemia = mag > _____ mEqs/L
2.5
Hypermagnesemia associated with….
Acute or chronic renal failure
Toxemia from magnesium therapy
Overadmin if magnesium containing compounds (ie antacids, cathartics)
Hypermagnesemia s/s
Skeletal muscle weakness
Can lead to respiratory arrest
Vasodilation, hypotension
Myocardial depression, hypotension
Complete heart block
Hyporeflexia, diminished DTR
sedation
Hypermagnesemia tx….
Stop mag therapy/intake- (often infused in OB)
Increase excretion (loop diuretic)
Antagonize CV or NM toxicity with CaCl or Ca gluconate (transient effect, gives time to excrete mag)
Anesthetic considerations in Hypermagnesemia
Magnesium potentials the action of NDMR- NMB will last LONGER
Intubation for pt if respiratory reflexes become compromised (OB)
What type of calcium is measured (physiologically active) for our purposes
Ionized calcium
Calcium is found primarily in ____ and then _____ fluid
Bone
ECF
___- _____ % of calcium is protein bound to albumin in the plasma
40-45
Calcium is regulated by these two hormones—
And what endocrine organ!
Calcitonin
Parathyroid hormone
Parathyroid glands
_______ is essential for all movement, all normal excitation-contraction coupling of myocardial and skeletal muscle
Calcium
_________ is the neurotransmitter released into the synaptic gap
Calcium
______ causes the plateau phase of cardiac muscle cells
Calcium
Hypocalcemia-
Serum ca < ____ mg/dl
Ionized Ca< ____ mEq/L
8.5
2
Hypocalcemia etiologies;
Malabsorption
Increased excretion due to renal insufficiency
Hypoparathyroidism
Chelation from citrate in blood transfusions (transient, negligible unless renal/hepatic failure or hypothermia)
Shift into cell with alkalosis IE acute resp alkalosis (increased mV, this is the reason hyperventilation of anxiety can cause parasthesias of the lips)
Hypocalcemia: s/s
CNS; parasthesias (especially circumpolar) confusion, seizures
CV; decrease myocardial contractility, hypotension, cardiac failure, arrhythmias. Negative inotropy- decreased camp, decreased cardiac AP
NM; twitching, cramping, trousseaus sign, chevosteks sign, convulsions, laryngospasm
Major airway consideration/caution with hypocalcemia
Laryngospasms
Hypocalcemia/ effect on EKG
Prolonged QTC
Anesthetic considerations for hypocalcemia-
Replace calcium, evaluate pt history, renal function, serum phosphate (inversely proportional)
Avoid alkalosis- drives Ca into cells
Monitor Ionized calcium
Monitor patient with replacement