Electrochemical Action Of Neurons Flashcards
Conduction
Movement of an electrical signal within neurons: dendrites -> cell body -> axon
Transmission
Movement of a signal from one neuron to another as a result of chemical signalling across the synapse
Resting potential
Difference in electric charge between the inside and outside of neuron’s cell membrane
Action potential
Electrical signal conducted along the length of a neuron’s axon to a synapse
Why does an AP
When electrical charge reaches threshold level, sodium specific channels open and Na+ ions rush in
; this raises the charge of the inside
Saltatory conduction
Electric current passing down the length of a myelinated axon
Nodes of Ranvier
Charge jumps from node to node along the axon
Transmission between neurons Terminal buttons
Knoblike structures at the end of an axon and are filled with vesicles containing neurotransmitters
Neurotransmitters
Chemicals that transmit information across the synapse to a receiving neurons dendrites
Receptors
Parts of the cell membrane that receive NTs and either initiate or prevent a new electric signal
Reuptake
NTs are absorbed by the terminal buttons of the presynaptic neurons axon or neighbouring glial cells
Diffusion
NTs drift out of the synapse and can no longer reach receptors
Autoreceptors
NTs can bind receptor sites on presynaptic neurons; release signal to stop releasing NTs if there is excess
Acetylcholine (ACh)
Voluntary motor control; regulation of attention, learning, sleeping, dreaming, memory, deterioration = Alzheimer’s
Glutamate
Excitatory NT; enhances transmission of info between neurons; too much = seizures
GABA
Inhibitory NT;stops firing of neurons; too little = seizures
Norepinephrine
Mood and arousal; states of vigilance and awareness of dangers; low levels = mood disorders
Serotonin
Mood and arousal; regulation of sleep and wakefulness , eating, aggressive behaviour,
; low levels = mood disorders
Endorphins
Act within pain pathways and emotion centres; dulls experience of pain and elevates mood
Agonist
Increase action of a NT, binds to a receptor and activates the NT
Antagonist
Diminish function of a NT; prevents the NT from acting or lessens it’s effect
L-Dopa
When modified produces dopamine; ingestion causes neurons to produce more dopamine; agonist for dopamine
Amphetamines
Stimulates release and prevents reuptake of norepinephrine and dopamime; excess NTs flood the synapse which increases activation of the receptors; agonists
Opioids
Agonist for endorphins; feeling of calm and euphoria; effective antagonist that decreases the release of NTs involved I’m perception of pain
Naloxone
Opioid; antagonist as it binds to opioid receptors blocking agonist from affecting neurons
Prozac
Blocks reuptake of serotonin- SSRIs keeps serotonin in synapse longer to activate more receptors to improve mood; agonist for serotonin
Propranolol
Beta blockers; blocks receptor site for norepinephrine in the heart; antagonist for NE as it prevents NE from binding to receptos which slows down the heart; anti-anxiety, antidepressants