electrical activity of the heart Flashcards

1
Q

what are the 2 types of cardiac muscle cells

A

contractile (99%)
autorythmic (1%)

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2
Q

t/f each type of myocardium cell has a distinctive action potential

A

True

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3
Q

cardiac has the ability to generate

A

action potentials

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4
Q

what percent of myocardial cells can generate action potentials simultaneously?

A

1

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5
Q

t/f the heart can contract without an outside signal

A

True

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6
Q

why can the heart contract without an outside signal?

A

it is myogenic, originating within the heart itself

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7
Q

define autorythmicity

A

The heart contracts, or beats, rhythmically due to the action potentials that it generates by itself

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8
Q

T/F the signal for myocardial contraction does NOT come from the nervous system but from specialized myocardial cells also called autorythmic cells

A

true

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9
Q

autorythmic cells are also called

A

pacemaker cells

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10
Q

pacemaker cell st the

A

rate of heartbeat

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11
Q

autorythmic cells do not contribute to the contractile force of the heart because

A

they do not have organized sarcomeres

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12
Q

myocardial contractile cells are also known as

A

working myocardium

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13
Q

working myocardial cells include

A

atrial and ventricular muscle

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14
Q

the conduction system is made of

A

specialized myocytes

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15
Q

myocytes can propagate

A

electrical current

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16
Q

role of the conduction system is

A

Initiation of the heartbeat
Coordination of the heartbeat

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17
Q

components of the conduction system

A

Sinus (sino-atrial) node
Atrioventricular (AV) node
His-Purkinje system
Bundle of His
Left bundle branch
Anterior fascicle
Posterior fascicle
Right bundle branch
Purkinje fibers

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18
Q

location, role and structure of the sinus node

A

location: right atrium at junction between cranial vena cava and atrium
role: normal pacemaker and initiates the impulse
structure: pacemaker cells

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19
Q

t/f In most species, the initiation of the impulse can occur anywhere between the cranial and caudal vena cava

A

true

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20
Q

what causes atrial depolarization?

A

Cardiac impulse propagates
-Right to left
-Top to bottom (base to apex)
Cell-to-cell propagation
No specialized conduction system within the atria

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21
Q

where is located and what is the role of the atrioventricular node?

A

location: base of the interventricular spetum
role: ONLY CONDUCTION PATHWAY

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22
Q

role of His left and right bundles

A

conducting an impulse rapidly from AV node to apex of the heart.

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23
Q

the His right bundle branch is isolated from

A

myocytes until it reaches the cardiac apex

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24
Q

the His left bunddle branch has connections with

A

myocytes un the interventricular septum

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25
Q

role of purkinje fibers

A

Propagate impulse rapidly to ventricular myocytes

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26
Q

in relation to the purkinje fibers, the depolarization starts at

A

apex and propagates to the base, ventricular contraction starts at the apex the apex and propagates to the base

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27
Q

t/f a pacemaker can geneate a stimulus simoultaneously

A

true

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28
Q

name the physiological pacemakers

A

Sinus node / AV node / Purkinje fibers

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29
Q

rate of depolarization can be modulated by autonomic influences

A

PSNS
SNS

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30
Q

WHICH is the faster pacemaker that controls the electrical activity?

A

sinus node

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31
Q

if the sinus node malfunctions, who takes over?

A

AV node

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32
Q

if the AV node malfunction, who takes over?

A

Purkinje fibers

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33
Q

electrical impulse transmission between myocytes is possible due to

A

intercalated disks that connect myocytes end to end formed by
desmosomes
gap junctions

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34
Q
A
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35
Q

desmosome are

A

mechanical connections

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36
Q

gap junctions are

A

electrical connections

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37
Q

The rapid propagation of impulses allows

A

contraction of cardiac chambers as a unit

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38
Q

Cells of the conduction system are wider and contain more

A

gap junctions = faster conduction

39
Q

Gap junctions are rare between cells of

A

AV node = slow conduction

40
Q

roles of the conduction system

A

initiation of electrical impulses = within the heart by pacemaker cells
propagation of electrical impulse = specialized myocytes

41
Q

t/f an isolated heart can still beat at a regular rate

42
Q

propagation of cardiac action potential

A

change of cell membrane voltage in pacemaker cells
ions moving across the membrane : Na, K and Ca

43
Q

the inside of the cell membrane of pacemaker cells is more

44
Q

the outside of the cell membrane of pacemaker cells is more

45
Q

describe the biological curents of Na, K and Ca

A

more Na outside the cell, channels open for Na to enter
more K inside the cell, channels open for K to efflux
more Ca outside the cell, channels open for Ca to enter and has a extracellular and intracellular [] gradient because Ca is secuestrated in the sarcoplasmic reticulum

46
Q

at rest, the ventricular myocytes are at a voltage of

A

-80 to -90

47
Q

the duration of the cardiac action in a ventricular cell potential is

48
Q

during phase 0, the ventricular cell is

A

depolarized
Na open
K closed
Ca closed

49
Q

during phase 4, ventricular cells are

A

at resting potential
it is negative inside the cell

50
Q

t/f during phase 0, another new action potential can be generated

51
Q

during phase 1 od the action potential in ventricular cells, the ion channels are (Na, K , Ca)

A

Na+ channels inactivated
K+ channels open
Ca++ channels closed

52
Q

when K flowa out of the cell, the membrane potential becomes more

53
Q

During phase 2 of the action potential in the ventricular cells, what happens with the ion channels (Na, K, Ca)

A

plateau
Na+ channels inactivated
Ca++ channels open = enters the cell
K+ channels open = leaves the cell
balance between Ca and K

54
Q

During phase 3 of the action potential in the ventricular cells, what happens with the ion channels (Na, K, Ca)

A

repolarization
Na+ channels inactivated
Ca++ channels closed
K+ channels open = exit the cell

55
Q

what enzyme is involved in phase 3 and what is it’s role?

A

ATPase
Na+/K+ ATPase pump restores equilibrium
Ca++ ATPase pump moves Ca++ out of cell

56
Q

refractory period

A

Time between beginning and end of an action potential

57
Q

why can’t an electrical impulse depolarize a myocyte before the end of an ongoing action potential?

A

due to the Na channels
They can exist in 3 states: open, inactivated and closed
They are blocked in inactivated state after phase 0
They return to a closed state when membrane potential back to -80 mV

58
Q

what is the role of the refractory period?

A

prevents repetitive cardiac contractions
absolute refractory period = impossible to occur another action potential at this time
relative refractory period

59
Q

define relative refractory period

A

A second action potential is unlikely but possible if high energy stimulus

60
Q

stages of the action potential in myocytes ventricular cells

A

Depolarization
Rapid Repolarization
Plateau
Repolarization

61
Q

what happens during depolarization in myocytes?

62
Q

what happens during rapid repolarization in myocytes?

63
Q

what happens during the plateau in myocytes?

A

Calcium Influx

64
Q

what happens during repolarization in myocytes?

65
Q

what is distinct about the pacemaker cells “resting membrane potential” and what do they actually have?

A

do not have a stable resting membrane potential like the nerve and the skeletal muscles, they have a PACEMAKER POTENTIAL.
have an unstable membrane potential that starts at – 60mv and slowly drifts upwards towards threshold.

66
Q

What causes the pacemaker potentials of these cells to be unstable?

A

permeability to Na and K, leading to the influx of both at the same time. This net influx slowly depolarized leading to the opening of the calcium channels.

67
Q

ionic basis of the action potential in pacemaker cells

A

Phase 1: Pacemaker Potential
phase 2: the rising phase or depolarization
phase 3: the falling phase or repolarization

68
Q

ions associated with the pacemaker potential

A

Opening of voltage-gated Na channels
Closure of voltage-gated K channels.
Opening of Voltage-gated Transient-type Calcium

69
Q

ions associated with the pacemaker potential during the rising phase or depolarization

A

Opening of Long-lasting voltage-gated Calcium channels
Large influx of Calcium.

70
Q

ions associated with the pacemaker potential during the falling phase or repolarization

A

Opening of voltage-gated Potassium channels
Closing of Long-type Ca channels.
Potassium Efflux.

71
Q

nodal cells, sinus, and atrioventricular cells action potential stages

A
  1. Baseline potential = - 60 mV, Spontaneous depolarization, Net influx of Na+ (If channels)
  2. threshold (-40 mV), Ca++ channels open and Influx of Ca++
  3. When membrane potential reaches 0 mV, K+ channel open
    and Efflux of K+
    4.Repolarization to -60 mV
72
Q

what cells are associated with these characteristics?
Spontaneously depolarize
Upstroke action potential
Depends on Ca++ channels
No Na+ channels
No plateau phase

A

pacemaker cells

73
Q

what cells are associated with these characteristics?
No spontaneous depolarization
Upstroke action potential
Depends on Na+ channels
Na+ channels
Plateau phase (phase 2)

A

atrial and ventricular myocytes

74
Q

what tone is associated with these characteristics
Sympathetic nerves
Neurotransmitter: Norepinephrine
Receptor: Beta receptor (beta 1 and 2)
Adrenal glands
Epinephrine, norepinephrine
Receptor: Beta receptor (beta 1 and 2)

A

adrenergic tone

75
Q

what nerve is associated with these characteristics?
Parasympathetic nerves
Neurotransmitter:Acetylcholine (Ach)
Receptor: Muscarinic receptor

A

vagal nerve

76
Q

what effects causes the adrenergic tone on the sinus node?

A

Increases heart rate
Increases firing of sinus node
Makes membrane more permeable to Na+
Makes Ca-channel more permeable to Ca++
Increases rate of depolarization

77
Q

what effects causes the vagal tone (psns) on the sinus node?

A

slows heart rate
decreases firing of sinus node
Acetylcholine (Ach) stimulates K channels (IK(Ach))
More K+ leaves the cell
Opposes effects of If
Takes more time to reach threshold

78
Q

the SNS acts on myocytes specifically on what type of receptors

A

Beta-receptors (mainly beta-1)

79
Q

effects of the SNS on myocytes

A

Shortens action potential in all cells
Allows faster conduction of impulses
Increases rate of depolarization in pacemaker cells
Increases rate of sinus node discharge
Increases conduction of impulses through AV node
Increases the strength of contraction
Strength of contraction related to amount of Ca++ entering cells

80
Q

Effects of parasympathetic system on myocytes

A

Effect on sinus node
Slows depolarization
Slows pacemaker rate discharge
Effect on atrioventricular node
Decreases conduction velocity = slows impulse propagation to the ventricles
No direct effect on ventricular myocytes (lack of innervation to the ventricles)

81
Q

excitation and contraction coupling

A

Ca++ enters cell during phase 2 action potential
Ca++ reaches inside of the cell through T-tubules
T-tubules are invagination of the membrane
T-tubules are rich in Ca++ channels
T-tubules are close to sarcoplasmic reticulum

82
Q

for the myocytes to contract, Ca has to bind to

A

myofilaments

83
Q

myofilaments in myocytes are

A

thin = actin, troponin and tropomyosin
thick = myosin

84
Q

actin, troponin and tropomyosin

A

thin filament

85
Q

myosin

A

thick filament

86
Q

contraction occurs when

A

myosin heads bind to actin

87
Q

what prevents fixation of myosin to actin

A

Troponin/tropomyosin complex

88
Q

what allows the binding of myosin and actin?

A

Ca++ binding to troponin

89
Q

realxation of the myocytes occurs when Ca is

A

actively reabsorbed into the sarcoplasmic reticulum
Ca++ is moved out of cell
Ca++ ATPase pump
Ca++/Na+ exchanger

90
Q

cardiac contraction depends on what ion?

91
Q

most of the calcium is stored in the

A

sarcoplasmic reticulum

92
Q

3 proteins that form troponin

93
Q

example of sympathomimetic drug

A

Dobutamine

94
Q

how does Dobutamine work?

A

Acts on beta1-receptors
Increases intracellular calcium = positive inotrope
Increases the rate of calcium reuptake in sarcoplasmic reticulum is diastole= positive lusitrope