Elective Pregnancy Termination Flashcards
What is the best method of pregnancy termination in a bitch not intended for breeding?
Ovariohysterectomy
Pregnancy Termination in Mares:
Before 35 days - __________________ injection of PGF2alpha is needed
Single
What is the method of pregnancy termination for the following species?
Mare
A single injection of PGF2alpha before 35 days of pregnancy
Why would we give oxytocin to a mare?
to cause big uterine contractions
Cattle are CL-dependent for the first part of their pregnancy and the last part of their pregnancy is when the _______________ takes over
Placenta
Prostaglandin drugs for cattle are:
- Lutalyse
- Cloprostenol
In cattle, after 150 days we have to do something to disrupt the placental source of progesterone. We do this by:
Giving Dexamethasone with the Prostaglandin (PGF2alpha)
(T/F) Goats are CL-dependent throughout their entire pregnancy
True
(T/F) In camelids, we can use either Lutalyse or Cloprostenol
False, we can only use Cloprostenol
Sheep are CL-dependent and then placental, just like the _______________
Cows
What is the method of pregnancy termination for the following species?
Goat
A single injection of dinoprost (LUTALYSE) at any point of pregnancy
What is the method of pregnancy termination for the following species?
Alpaca
A single injection of Cloprostenol (Estrumate) at any point of pregnancy
What is the method of pregnancy termination for the following species?
Bitch
Combination of PGF2alpha + dopamine agonist + prostaglandin E1
Dogs are a __________ dependent pregnancy
CL
A client with a valuable breeding bitch comes to you because she had an accidental breeding to her litter mate. She wants to know what the best option is in order to preserve her fertility. What is your recommendation?
Aglepristone (Alizin) injections
What is inversely proportional to Prolactin?
Dopamine (happy hormone)
Aborted fetuses may be alive
Advanced pregnancy (>50 days)
- Shorter, but effective treatment
- May pass aborted dead fetuses
Mid-pregnancy (30-40 days)
- Longer treatment times
- Minimal vulvar discharge
Pregnancy diagnosis (25-30 days)
- Higher dose & longer duration of treatment
- Few options
Early pregnancy (5-20 days diestrus)
What are the reasons why the use of “mismate shot” (ECP) is not recommended?
- Increased risk of cystic endometrial hyperplasia (CEH)
- Increased risk of bone marrow suppression
- Increased risk of pyometra
- Begin after day 35 gestation
- If > day 50 gestation - live, nonviable pups delivered - Inexpensive
- Preserves future fertility
- 80% effective
Dexamethasone (Glucocorticoids)
- Stronger dopamine receptor (D2) agonist
- Dose: 5 μg/kg PO SID x 5 days
- Compounding often necessary - Minimal side effects (vulvar discharge)
- No impact on fertility
- Used with PGF2a
Cabergoline
- Veterinary compound approved in Europe
- Progesterone Blocker
- Two 10 mg/kg injections
- SQ 24 hours apart - Fetal death within 5 days of treatment
- Rare chance of treatment failure
- Ultrasound needed to ensure efficacy
- If still pregnant -> repeat injections - Can be used during “early” or “late” pregnancy
- Early – 0-25 days
- Late – 26-45 days
Aglepristone (Alizin®)
- Never used alone
- Prostaglandin E1
- Adjunctive therapy
- Applied intravaginally or orally for cervical dilation
- 100-400 µg per bitch q24h
- Decreases treatment time
Misoprostol
- Reduce side effects
- Treat earlier
- Increase efficacy - Synergistic effect?
- Shorten abortion times
Mismate Combos
