Eicosanoids Flashcards
The leukotriene antagonist that is used for asthma prophylaxis
Zafirlukast
Zileuton
Endogenous eicosanoid that has cytoprotective role
PGE2
Zileuton blocks what enzyme
5-LOX
Zafirlukast blocks which receptor
CYSLT1 receptor
Glucocorticoids inhibit _______ directly & ________ indirectly
COX2 expression, phospholipase
Acetaminophen inhibits what enzyme
COX-3
Celexicob is a somewhat _____ inhibitor
COX-2
Which PG synthesis inhibitor can cause an allergic reaction in patients sensitized to sulfonamides?
Celexicob
Ibuprofen inhibits which enzymes?
COX 1/2
Aspirin inhibits which enzymes ?
COX 1/2
Possible side effects of NSAIDS
Ulcers
Weight gain
Arterial hypertension
Increased risk for thrombotic events
Eicosonoids used to manage glaucoma
Latanoprost
Bimatoprost
Side effects of latanoprost/bimatoprost
Pigmentation
Irritation/inflammation
Eyelash growth
Effects of Thromboxane A2
Vasoconstriction
Bronchoconstriction
Platelet aggregation
Function of leukotriene B
Chemotaxis & recruitment of inflammatory cells
Carboprost is a synthetic analog of
PGF2a
Prostaglandin that facilitates labor and induces abortion
PGF2a
Side effects of PGF2a
Bronchoconstriction
Nausea
Vomiting
Diarrhea
Effects of Prostaglandin D2
Vasodilation Plasma exudation Chemotaxis Inflammation Bronchoconstriction Sleep
The best prostaglandin for inducing labor
PGE2
Function of PGE1
Erectile dysfunction
Maintain patent ductus arteriosus
Prostaglandin used to maintain patent ductus arteriosus
PGE1
Prostaglandin used to treat pulmonary hypertension
PGI2
Lubiprostone target
Agonist at Cic2 chloride channels
What lubiprostone treats
IBS, constipation
Side effects of lubiprostone
Nausea
Diarrhea
Effects of PGE2
Inhibits ADH
Natriuresis
Vasodilation
Inflammation
