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Pharm > Eicosanoids > Flashcards

Eicosanoids Flashcards

0
Q

The leukotriene antagonist that is used for asthma prophylaxis

A

Zafirlukast

Zileuton

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1
Q

Endogenous eicosanoid that has cytoprotective role

A

PGE2

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2
Q

Zileuton blocks what enzyme

A

5-LOX

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3
Q

Zafirlukast blocks which receptor

A

CYSLT1 receptor

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4
Q

Glucocorticoids inhibit _______ directly & ________ indirectly

A

COX2 expression, phospholipase

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5
Q

Acetaminophen inhibits what enzyme

A

COX-3

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6
Q

Celexicob is a somewhat _____ inhibitor

A

COX-2

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7
Q

Which PG synthesis inhibitor can cause an allergic reaction in patients sensitized to sulfonamides?

A

Celexicob

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8
Q

Ibuprofen inhibits which enzymes?

A

COX 1/2

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9
Q

Aspirin inhibits which enzymes ?

A

COX 1/2

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10
Q

Possible side effects of NSAIDS

A

Ulcers
Weight gain
Arterial hypertension
Increased risk for thrombotic events

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11
Q

Eicosonoids used to manage glaucoma

A

Latanoprost

Bimatoprost

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12
Q

Side effects of latanoprost/bimatoprost

A

Pigmentation
Irritation/inflammation
Eyelash growth

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13
Q

Effects of Thromboxane A2

A

Vasoconstriction
Bronchoconstriction
Platelet aggregation

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14
Q

Function of leukotriene B

A

Chemotaxis & recruitment of inflammatory cells

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15
Q

Carboprost is a synthetic analog of

A

PGF2a

16
Q

Prostaglandin that facilitates labor and induces abortion

A

PGF2a

17
Q

Side effects of PGF2a

A

Bronchoconstriction
Nausea
Vomiting
Diarrhea

18
Q

Effects of Prostaglandin D2

A 
Vasodilation
Plasma exudation 
Chemotaxis
Inflammation
Bronchoconstriction 
Sleep
19
Q

The best prostaglandin for inducing labor

A

PGE2

20
Q

Function of PGE1

A

Erectile dysfunction

Maintain patent ductus arteriosus

21
Q

Prostaglandin used to maintain patent ductus arteriosus

A

PGE1

22
Q

Prostaglandin used to treat pulmonary hypertension

A

PGI2

23
Q

Lubiprostone target

A

Agonist at Cic2 chloride channels

24
Q

What lubiprostone treats

A

IBS, constipation

25
Q

Side effects of lubiprostone

A

Nausea

Diarrhea

26
Q

Effects of PGE2

A

Inhibits ADH
Natriuresis
Vasodilation
Inflammation

Pharm (6 decks)

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