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26 Autacoids > Eicosanoids > Flashcards

Eicosanoids Flashcards

1
Q

Eicosanoid synthesis inhibitors (3 groups)

A

Leukotriene inhibitors
NSAIDs
Corticosteroids

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2
Q

Prostaglandin E1 agonists (2 drugs)

A

Alprostadil

Misoprostol

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3
Q

Alprostadil - indications

A

Maintaining patent ductus arteriosis

Erectile dysfunction

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4
Q

Alprostadil - adverse effects

A

Penile pain & fibrosis, priapism

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5
Q

Misopristol - indications

A 
NSAIDs treatment (prevent ulcers)
Abortifacient
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6
Q

Misoprisol is used as abortifacient with …?

A

Mifepristone

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7
Q

Misopristol - contraindications

A

Pregnancy (cause uterine contractions)

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8
Q

Misopristol - adverse effects

A

Uterine contractions & premature labor

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9
Q

PGE2 analogue (1 drug)

A

Dinoprostone

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10
Q

PGF2alpha agonists (4 drugs)

A

Carbaprost tromethamine
Latanoprost
Bimatoprost
Travoprost

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11
Q

Dinopristone - indications

A

Labor induction - cervical ripening

Evacuate uterine contents

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12
Q

Dinopristone + Carbaprost tromethamine - MOA

A

Ocytocic activity - uterine contractions in pregnancy

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13
Q

Carbaprost tromethamine - indications

A

Postpartum bleeding

Abortifacient

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14
Q

Carbaprost tromethamine - adverse effects

A

Altered BP
Blurred vision
Respiratory distress

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15
Q

PGF agonists used for open angle glaucoma (3 drugs)

A

Latanoprost
Bimatoprost
Travoprost

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16
Q

PGF agonists used for ocular hypertension (2 drugs)

A

Bimatoprost

Travoprost

17
Q

Prostacyclin analogues (2 drugs)

A

Epoprostenol

Treprostinil

18
Q

PGI2 analogues - indications

A

Pulmonary arterial hypertenstion

19
Q

Epoprostenol - adverse effects

A

Tachycardia, hypotension

20
Q

Endothelin-1 antagonists (2 drugs)

A

Bosentan

Ambrisentan

21
Q

Eicosanoid-associated drugs used for pulmonary arterial hypertension (4 drugs + their groups)

A

PGI2 analogues: epoprostenol, treprosteinil

ET antagonists: bosentan, ambrisentan

22
Q

Bosentan - contraindications

A

Pregnancy

26 Autacoids (3 decks)

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