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26 Autacoids > Antihistamines (H1 antagonists) > Flashcards

Antihistamines (H1 antagonists) Flashcards

1
Q

What groups of antihistamines are there?

A

4 generations

Intranasal + ophthalmic

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2
Q

Which antihistamine is most active for allergic reactions?

A

All are equally active for allergic reactions

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3
Q

1st generation antihistamines (8 drugs)

A 
Chlorpheniramine
Clemastine
Dimenhydrinate
Diphenhydramine
Hydroxyzine
Meclizine
Promethazine
Doxepin.
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4
Q

1st generation antihistamines - adverse effects

A 
Sedation
Children: cause excitement
Dry mouth
Blurred vision
Tachycardia
Urinary retention
Hallucinations
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5
Q

1st generation antihistamines with least sedating effect (1 drug)

A

Chlorpheniramine

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6
Q

1st gen antihistamines with highest sedating effect (3 drugs)

A

Dephenhydramine
Hydroxyzine
Promethazine

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7
Q

1st gen antihistamines used for vertigo and motion sickness (2 drugs)

A

Dimenhydrinate

Meclizine

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8
Q

1st gen antihistamines with higher incidence of adverse effects (2 drugs)

A

Diphenhydramine

Promethazine

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9
Q

1st gen antihistamines used for: Induce sleep, pre-op sedation, distress from severe pruritus (4 drugs)

A

Diphenhydramine
Hydroxyzine
Promethazine
Doxepin

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10
Q

Doxepin - indications (that are special for this drug)

A

Antidepressant, anxiolytic.

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11
Q

2nd gen antihistamines (4 drugs)

A

Cetrizine
Fexofenadine
Loratadine
Desloratadine

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12
Q

2nd gen antihistamines - indications

A

Allergic reactions

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13
Q

Which 2nd gen antihistamine can cause some sedation?

A

Cetrizine

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14
Q

Antihistamine for intranasal adm (1 drug)

A

Azelastine

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15
Q

Azelastine - indications

A

Allergic rhinits

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16
Q

Azelastine - adverse effects

A 
Drowsiness
Fatigue
Nasal irritation
Dry mouth
Weight gain
17
Q

Antihistamines for ophthalmic use (4 drugs)

A

Levocabastine
Epinastine
Olopatadine
Ketotifen

18
Q

Ophthalmic antihistamines - indications

A

Allergic conjunctivitis

26 Autacoids (3 decks)

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