Eicosanoids

Question 1

PGI2

Answer 1

COX Pathway
vasculature, stomach
vasodilation, (-) platelet aggregation
also: (-) gastric acid, (+) mucus in stomach

Question 2

PGE2

Answer 2

Cox pathway
uterus; induction of labor; (+) uterine contraction
AE: fever, pain, (-) gastric acid, diarrhea

Question 3

PGF2alpha

Answer 3

COX pathway

uterus, induction of labor/abortion; (+) uterine contraction

Question 4

TXA2

Answer 4

COX pathway
platelets; (+) platelet aggregation; vasoconstriction
TBX2 is a product

Question 5

misoprostol

Answer 5

COX pathway
induction of labor/abortion
+ uterine contraction
also used to treat ulcers

Question 6

corticosteroids

Answer 6

COX and lipogenase pathways
anti-inflammatory
(-) formation of free arachidonic acid

Question 7

LTB4

Answer 7

lipoxygenase pathway
BLT1 receptor
attracts neutrophils

Question 8

LTC4

Answer 8

lipoxygenase pathway
cysLT2 receptor
causes edema

Question 9

LTD4

Answer 9

lipoxygenase pathway
cysLT1 receptor
causes bronchoconstriction

Question 10

Zileuton (Zyflo)

Answer 10

lipoxygenase pathway
MCU: asthma, allergies
MO: (-) 5-Lipoxygenase

Question 11

lipoxygenase pathway

Answer 11

• mainly WBC and plateletes
  LTB, LTC, TLD - constrictors in coronary and pulmonary circulation
  LTB requires neutrophil
  LTC and LTD have direct effect on endothelium

Question 12

EP3 receptor

Answer 12

important for fever response