Eicosanoid

Question 1

prostaglandin analogue used in glaucoma

Answer 1

latanoprost
PGF2alpha

SE:dark pigmentation of iris

Question 2

PDA

1. open
2. close

Answer 2

1. open - alprostadil(PGE1)

2. close- indomethacin

Question 3

role of LTs

Answer 3

LTB4- neutrophil chemoattractant

LTA4, LTC4 , LTD4- anaphlaxis and bronchoconstriction

Question 4

glucocorticoids inhibit

Answer 4

phospholipase A2(prevent arachdonic acid fomation)

Question 5

zileuton blocks

Answer 5

LOX

Question 6

platelet TXA2 formed by which COX

Answer 6

COX1

Question 7

effect of PGs on uterus

Answer 7

increase contractions
1.abortifacient

2.NSAIDs can decrease primary dysmenorrhoea

Question 8

PG used in pul htn

Answer 8

epoprostenol

Question 9

actions of ASA are dose dep

Answer 9

less to more dose

antiplatelet

analgesic and antipyretic

antiinflammatory

Question 10

effect of ASA on resp

Answer 10

HIGH THERAPEUTIC DOSE
mild uncoupling of OP
inc in resp
resp alkaosis
comp resp alkalosis

TOXIC DOSES

1. inhibit resp doses- resp acidosis
2. uncoupling of OP- met acidosis

Question 11

hypersensitivity of ASA triad

Answer 11

asthma
nasal polyps
rhinitis

Question 12

effect os aspirin on uric acid level

Answer 12

LOW TO MODERATE:hyperuricemia
(dec tub secretion by using transport)

HIGH:uricouria
(dec tubular reabsortion by damaging)