EI fragmentation

Question 1

Derivitisation

Answer 1

Transforms chemical compound into a product (derivate) of similar chemical structure

Question 2

2 purposes of derivitisation in EI

Answer 2

Convert involtaile substances to volatile (molecule has to be in gas phase) and directing fragmentation

Question 3

Examples of derivitisations

Answer 3

Acetylation (NH2 and OH), methylation (OH, amide, thiol), esterification (acids), conversion (ketones to ketals), trimethylsilylation

Question 4

Even electron rule

Answer 4

An even electron ion won’t normally fragment to 2 odd species

Question 5

Types of elimination

Answer 5

Radical or neutral

Question 6

Types of radical elimination

Answer 6

Alpha or beta

Question 7

What is neutral elimination?

Answer 7

When a stable neutral molecule (water) can be readily formed via a 1,2 elimination mechanism

Question 8

Induction cleavage

Answer 8

Initiation of cleavage reaction by the positive charge involves attraction of an electron pair

Question 9

McLafferty rearrangement

Answer 9

Fragmentation occurs via bond forming and bond breaking