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Cardiovascular Physiology > Efferent Autonomic Regulation > Flashcards

Efferent Autonomic Regulation Flashcards

1
Q

What is chronotropy?

A

Modulation of heart rate

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2
Q

What is Inotropy?

A

Modulation of force of contraction

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3
Q

What is lusitropy?

A

Modulation of rate of relaxation

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4
Q

What is dromotropy?

A

Modulation of conduction through AV node

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5
Q

Where can adrenaline and noradrenaline be secreted from?

A

Chromaffin cells in adrenal gland

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6
Q

What nerve is involved with parasympathetic stimulation of the heart?

A

Vagus nerve (cranial nerve X)

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7
Q

Where does the vagus nerve originate from in the brain?

A

Nucleus Ambiguus (NA)
Dorsal Vagal Motor Nucleus (DVMN)

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8
Q

Where does the sympathetic innervation of the spinal cord arise from?

A

Rostral Ventrolateral Medulla

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9
Q

What receptor does ACh bind to on the spinal cord?

A

Nicotinic receptors

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10
Q

What is the neurotransmitter involved with the parasympathetic response?

A

ACh

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11
Q

What does ACh bind to in the cardiac and smooth muscles?

A

M2 receptors

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12
Q

What is the neurotransmitter involved with the sympathetic response?

A

Noradrenaline

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13
Q

What receptors does NA bind to in cardiac and smooth muscles?

A

Alpha adrenoreceptors
Beta 1 adrenoreceptors

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14
Q

What happens to the pacemaker potential during sympathetic stimulation?

A

Increase in slope -> reaches threshold quicker -> increases HR

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15
Q

What happens to the pacemaker potential during parasympathetic stimulation?

A

Decrease in slope -> takes longer to reach threshold -> slows down HR

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16
Q

What causes parasympathetic effects to be rapid?

A

Short signalling cascade
Effect of acetylcholinesterase

17
Q

What does cAMP affect?

A

Increases permeability of F-type channels -> causes depolarization
Activates protein kinase A

18
Q

What does protein kinase A affect?

A

Increases permeability of L-type Ca2+ channels-> increases pacemaker potential
Activates Kv channels -> commences repolarization

Cardiovascular Physiology (21 decks)

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