Effect Of Liver Dysfunction Flashcards
1
Q
Which cytochrome does metabolism occur in
A
CYP450 located in hepatocytes
2
Q
Why is blood flow through the liver reduced in cirrhosis?
A
There is increased vascular resistance affecting drug transportation and metabolism
3
Q
How does cirrhosis decrease plasma protein binding
A
Decrease albumin and alphas acid glycoprotein synthesis
Accumulation of bilirubin inhibiting plasma protein binding
Changes in albumin and alpha acid glycoprotein structure
4
Q
Why is there a weak CYP450 system in a cirrhotic liver?
A
There is a lack of oxygen, due to lack of oxygen and drug uptake
