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Infectologia > Efectos adversos > Flashcards

Efectos adversos Flashcards

1
Q

Efecto adverso aminoglucocido

A

1-Nefrotoxico (Especialmente la Gentamicina)
2-Ototoxico (Especialmente la Estreptomicina). Daña NCVIII
3-Bloqueo Neuromuscular (Impide liberacion de ACH en la placa neuromuscular, no se libera calcio sarcoplasmic. Paro respiratorio en miastenia gravis, hipomagnesemia e hipocalemia, uso de relajantes musculares y calcio antagonistas o administracion rapida o sin diluir. TX Gluconato de calcio y ventilacion)
4-Psuedosepsis (Se comporta como hapteno, desencadena SIRS, hemograma no alterado o no altera hemograma)

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2
Q

Sindrome de Jarish-Herxheimer

A

El bactericida lisa la bacteria y el material interno pasa a la circulacion se comporta como un antigeno. Ejemplo: Tratamiento leptospira

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3
Q

Prolongacion del cute

A

Quinolonas y Macrolidos

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4
Q

Alteraciones gastrointestinales

A

Daptomicina, Tetraciclinas, Macrolidos, Cloranfenicol, Nitrofurantoina y Fosfomicina

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5
Q

Ruptura del tendon de Aquiles

A

Quinolonas

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6
Q

Afeccion del crecimiento del hueso

A

Quinolonas y Tetraciclinas

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7
Q

Afeccion esmalte dental en menos de 8 años

A

Tetraciclinas

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8
Q

Hipersensibilidad

A

Penicilinas, Cefalosporinas, Carbapenemicos, Sulfonamidas, Cloranfenicol, Nitrofurantoina y Fosfomicina

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9
Q

Mielotoxicidad

A

Anemia: Sulfonamidas, Tetraciclinas y Cloranfenicol
Trombocitopenia: Linezolid, Vancomicina y Sulfonamidas

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10
Q

Reduce el umbral combulsivo

A

Penicilina, Carbapenemicos, Cefalosporinas

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11
Q

Nefrotoxicidad

A

Aminoglucocidos, Vancomicina, Polimixinas

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12
Q

Ototoxicidad

A

Aminoglucocidos, Vancomicina

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13
Q

Epatotoxicidad

A

Tetraciclina y Fosfomicina

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14
Q

Bloqueo neuromuscular

A

Aminoglucocidos y Clindamicina

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15
Q

Sindrome de hombre rojo

A

Vancomicina

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16
Q

Sindrome del hombre gris

A

Cloranfenicol

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17
Q

Rabdomiolisis

A

Daptomicina

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18
Q

Neuritis optica

A

Linezolid, Cloranfenicol y Etanbutol

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19
Q

Hiperpigmentacion de la lengua

A

Linezolid

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20
Q

Sindrome Serotoninergico

A

Linezolid

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21
Q

Flevitis en lugar de venopuncion

A

Vancomicina

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22
Q

Pseudosepsis

A

Aminoglucocidos

23
Q

Aumenta las xantinas

A

Macrolidos

24
Q

Hiperperistaltismo

A

Sulfonamidas y Clindamicina

25
Q

Efecto disulfiran

A

Metronidazol

26
Q

Diarrea por C. Dificile

A

Clindamicina

27
Q

Diabetes insipida nefrogenica

A

Tetraciclinas

28
Q

Fotosensibilidad

A

Quinolonas, Tetraciclina y Sulfonamidas

29
Q

Kernicterus

A

Sulfas

30
Q

Cristaluria

A

Sulfonamidas

31
Q

Sobre infeccion

A

Tetraciclina, Sulfonamidas, Macrolidos y Fosfomicina

32
Q

Disminuye la eficacia de ACO

A

Penicilina, Cefalosporinas, Tetraciclinas, Sulfonamidas, Macrolidos y Metronidazol

33
Q

Flebitis

A

Tetraciclina

34
Q

Sindrome Psuedolupico

A

Tetraciclina

35
Q

Vertigo

A

Tetraciclina

36
Q

Inhibicion

A

Penicilinas y Macrolidos

37
Q

Induccion del CYP450

A

Macrolidos

38
Q

Estenosis (Hipertrofia) Pilorica

A

Macrolidos

39
Q

Malfomarcion cardiaca

A

Macrolidos

40
Q

Enfermedades vasculares

A

Quinolonas y Macrolidos

41
Q

No elimina el estado de portador de estreptococo

A

Quinolonas, Tetraciclinas y Sulfonamidas

42
Q

Deficit de vitamina K por disbacteriosis intestinal

A

Carbapenemicos, Linezolid, Vancomicina, Metronidazol, Cloranfenicol, Clindamicina

43
Q

Barro Biliar

A

Cefalosporinas

44
Q

Fibrosis pulmonar irreversible

A

Nitrofurantoina

45
Q

Paralisis del NC VII

A

Nitrofurantoina

46
Q

Neumonitis alergica

A

Nitrofurantoina

47
Q

Tos y broncoespasmo

A

Nitrofurantoina

48
Q

Hemorragia digestiva

A

Nitrofurantoina

49
Q

Interaccion medicamentosas

A

Metronidazol

50
Q

Bacterioestaticos

A

Oxasolidinonas, Clindamicina, Quinopristina/Dalfopristina, Tetraciclina, Macrolidos y Cloranfenicol

51
Q

Mecanismo de accion con sintesis de la pared

A

Penicilina, Cefalosporina, Carbapenemicos, Monobactamicos, Fosfomicina, Polimixina, Acido Fusidico, Glucopeptido(Alanina-Alanina) y Lipopeptido( Receptores de calcio dependiente)

52
Q

Mecanismo de accion que interfiere con los acidos nucleicos

A 
Quinolona: Con la topoisomerasa 2 y 4 (ADN)
Metronidazol (Desnaturaliza el ADN)
Sulfas (B9)
Mupirosina (ARN)
Nitrofurantoina (ADN)
53
Q

Mecanismo de accion que interfiere con la sintesis proteica

A 
Tetraciclinas(@30S)
Aminoglucosidos(@30S)
Oxazolidinonas(@50S)
Clindamicina (@50S)
Quinuspristina/Dalfopristina(@50S)
Macrolidos(@50S)
Cloranfenicol(@50S)
54
Q

Antibioticos que atraviesan VHE

A

C1G, Aminoglucocidos (solo menos de 28 dias) y Quinolonas, Penicilina anti staf (Piperacilina y Ticarcilina)
Penicilina cristalina, C2G pulmon (Sefuroxima), C4G Cefepime

Infectologia (10 decks)

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