EENT Flashcards
What causes bacterial pharyngitis
GABHS (strep throat)
What are (centor) symptoms of bacterial pharyngitis
Fever >38
tender ant. cervical lymph nodes
lack of cough
pharyngotonsillar exudate
How do you treat bacterial pharyngitis
1st: Penicillin (adjust with renal impairment)
2nd: Erythromycin (if allergic to penicillin)
How does penicillin work
inhibits bacterial cell wall synthesis
What are side effects of Penicillin
Hypersensitivity (rash, pruritus, etc)
Mild diarrhea
n/v
oral candidiasis
What should you monitor for when prescribing penicillin
Anaphylaxis at first dose Opportunistic infection (fever, chills, yeast infection, fatigue)
What are doses for bacterial pharyngitis
Penicillin VK (10 days)
Amoxicillin (10 days)
Penicillin G Benzathine
^ plus Penicillin G procaine
What does Penicillin interact with
Probenecid
Tetracyclines (bacteriostatic w/ bactericidal)
Enhances anticoagulant effect of vitamin K antagonist
How does Erythromycin work
inhibits bacterial transcription and translation
What are side effects of erythromycin
Abd pain anorexia diarrhea QTc prolongation Ototoxicity (hearing loss)
What side effects require immediate reporting
Malaise N/V abd colic fever skin rash/itching easy bruising
What are dosages of Erythromycin
Erythromycin
Erythromycin Ethylsuccinate
Asithromycin
What does Erythromycin interact with
Effects of CYP450
It is a substrate of CYP2B6/3A4
It inhibits CYP3A4
What is the off-label use of Erythromycin
Gastrointestinal pro kinetic
What is the cause of acute laryngitis
Usually viral!
M. Catarrhalis, H. Influenza
