ED Flashcards
How many millions of men in the US are affected?
20 million
Most common in men over the age of
65
What are organic causes of ED? (80-90% over the age of 40)
- Vascular
- Neurogenic
- Hormonal
- Medications
- Combined neurogenic-vascular
Most common causes in patients under the age of 40?
Psychogenic:
- Anxiety
- Depression
- Psychosis
- Chronic stress
- PTSD
Which nervous system is used for achieving an erection?
Autonomic
Steps of normal pathophysiology for achieving a raging erection
- Hypothalamic activation
- Local release of NO (local dilator), releases cGMP in smooth muscle surround vasculature
- Smooth muscle relaxation and blood flow (tumescence=engorgement)
- To turn off, phosphodiesterase metabolizes cGMP, and smooth muscle contracts (detumescence)
Pathophysiology of vascular ED with examples
Any condition or disease that results in restriction of blood flow to the penis. It prevents tumescence
-HTN, atherosclerosis
Pathophysiology of neurogenic ED with examples
Interruption in nerve impulses (initial activation of hypothalamic activation, autonomic dysfunction, etc)
-Stroke, MS,
Pathophysiology of hormonal ED with examples
Lack of sexual desire, libido, due to low testosterone or maybe high estrogen
-alcohol, cirrhosis
Pathophysiology of medicinal ED with examples
Interfere with blood flow or nervous system (agents such as antidepressants)
Diabetes causes what type of ED?
Vascular and neurogenic - combined
Is a high score on the IIEF test good or bad?
Good… low score is bad
How long must someone have sexual difficulty to be diagnosed with ED?
6 months
Serious complications with ED therapy
- Shock
- Priapism - erection lasting longer than 4 hours
- Abnormal heart rhythms
