Crohn's disease (IBD) Flashcards
Transmural (extends deep into the lining of the GI tract) inflammatory bowel disease that involves primarily the distal ileum and colon, but can affect any portion of the GI tract
Crohn’s disease
__-__ per 100,000 people every year
7-40
Slightly more common in (men / women)
Women
Bimodal with peak incidence between ___-___ and after ___
15-30; after 60
More frequent in which two races?
Caucasians and Ashkenazi Jews
More common in (urban / rural) environments
Urban
Environmental factor contributing to CD
Infectious microbial agents
Genetic factor contributing to CD
Risk increased 13-fold for first degree relative
Other factor contributing to CD
Smoking increases risk
General pathology of CD
Overly aggressive response to normal GI bacteria in genetically susceptible individuals
Excessive _____ cell activity causes an inflammatory response in those with CD
TH1
_____ cell, and cytokines such as _____, _____, and ____ contribute to the development of CD
Macrophage cells; TNF-alpha, IL-1, IL-6
Most cases of CD involve the _____ and/or _____.
Ileum and/or colon
What are characteristics of the pathology of CD? (3)
- Sharply defined lesions surrounded by normal tissue
- Entire thickness of bowel wall inflamed
- Formation of abbesses, strictures, fissures, and fistulae
CD clinical presentation (10)
- Fever
- Fecal urgency with diarrhea
- Increased BMs
- Right lower quadrant pain
- Anal fissure
- Abscess
- Fistula
- Fatigue
- Weight loss
- Extraintestinal signs
