EC Chp 24 Hematologic & Renal Emergencies Flashcards
Blood has specific functions what are they?
Control bleeding by clotting
Delivery of oxygen to the cells
Removal of carbon dioxide from the cells
Removal and delivery of other waste profits to organs (kidneys and liver) that provide filtration and removal
Blood is made up of 4 components what are they?
Red blood cells
White blood cells
Platelets
Plasma
What is the special molecule in red blood cells that bind to oxygen and delivery it to cells
Hemoglobin
What do platelets do that is crucial?
Formation of clots which is also called clumping or AGGREGATION.
What is a situation would you not want clumping to occur in?
When plaque in a coronary artery ruptures. This could cause the rapid clumping and completely block the coronary artery which results in a heart attack (MI)
Plasma is the liquid in which blood cells and platelets are suspended but it also contains?
Dissolved nutrients and carries crucial proteins
Clotting factors in addition to platelets are proteins that are produced where?
In the liver
When are clotting factors activated?
When damage occurs to the lining of a damaged blood vessel
Clotting factors form clots through specific steps and they are called ?
Clotting cascades. They are the most stable clots, replacing the initial efforts of the platelets
Coagulopathy is
Loss of the normal ability to form a blood clot with internal or external bleeding
What are the results of coagulopathy.
The body forms clots too readily or too slowly resulting in uncontrolled bleeding. Possibly due to few platelets or they are not functioning correctly
What are certain diseases that make patients to poor clotting?
Advanced liver diseases
Cirrhosis - inadequate clotting factors
Hemophiliac- inherited disorder that don’t allow person to produce the clotting factors
Von Willebrands - most common inherited disease where platelets are functionally defective
Those at risk of for heart attack’s strokes or abnormal cardiac rhythms commonly take blood thinners. Examples are ?
Coumadin (warfin), pradaxa, eliquis, Xarelto, lovenox, which inhibit certain clotting factors
Other drugs such as asprin and plavix(clopidogrel) do what?
They inhibit platelet aggregation
Identifying patients with coagulopathies is based on medical history and medications they are taking. What is an important question to ask a trauma patient to find this out?
Are you on blood thinners?
Anemia is
The lack of a normal number of red blood cells in the circulation
Acute Anemia may be the result of what?
Trauma or sudden massive bleeding from GI tract. Will show signs and symptoms or shock
Chronic Anemia is and can be cussed from what?
Occurs over time and can be caused from heavy current menstrual periods, slow GI blood loss, or diseases that affect the bone marrow or Structure of the hemoglobin molecule.
Patients with chronic Anemia will appear…
More pale than normal, complain of fatigue, shortness of breath. Best way to examine is to check the conjunctiva which will be very pale.
Sickle cell anemia and an inherited disease in which results in a defect in the hemoglobin resulting in an abnormal structure of red blood cells. What are the most common patients of it?
- African
Middle eastern or Indian