EBV and CMV

Question 1

What is a chronic lytic infection? and what are the types?

Answer 1

Ongoing shedding of virus that does not immediately result in lysis of the cell

Focal and Diffuse!!

Ex) Hepatitis c….can progress into liver disease

Question 2

Describe DIFFERENT between chronic and latent virus is:

Answer 2

It is when there be viral nucleic acid, but cannot produces whole virus…

CH

Question 3

What type cells does EBV lie latent in? and CMV?

Answer 3

EBV enters B cells by attaching to the CD21 receptor types

Question 4

What type of cells does CMV reside in?

Answer 4

all types– macrophages, epithelials=

Question 5

How is EBV normally diagnosed?

Answer 5

MONOSPOT TEST!!!

smear– a typical lymphocytes

HETEROPHILE ANTIBODIES (does not fully confirm)

EBV specific antibodies and VIRAL CAPSID PROTEIN

Question 6

Is there a vaccine against EBV?

Answer 6

NO!!

Question 7

What are EBV associated illnesses?

Answer 7

Hairy Leukoplakia and Burkitts Lymphoma (mature b cell0 cd 15 and 30, not 45)

Question 8

How does EBV establish latency in B cells? In what DNA form? And what is the down stream effect?

Answer 8

As episomal DNA –> LATENT CELLS OVERPRODUCED IL-10 and cause hyperproliferation

Question 9

What will typically be seen on a smear for cytomagelovirus?

Answer 9

GIANT OWL EYES CELLS

Question 10

How and where does CMV maintain latency?

Answer 10

In many cell types, alter mhc1 not recognized by cg8 cells

Question 11

cmv clinical presentation?

Answer 11

blueberry muffin spots (not cmv specific), no het. igs.

In AIDS PATIENTS: retinitis, colitis, diarrhea

Question 12

WHAT IS THE BEST TREATMENT FOR CMV?

Answer 12

GAN and VALGAN- cyclovir are somewhat effective in retinitis and pnuemonia

There is no vaccine