Chemotherapy Drugs Rote Memorizations

Question 1

Name the the 4 parts of the cell cycle and the types of drugs that can inhibit them:

Answer 1

Mitotic phase—> microtubule inhibitors

S phase—> Antimetabolites/Topoisomerase inhibitors

G2 phase —-> DNA damaging agent, transcription inhibitors

ANDDDDD

Alkylating agents are phase non specific!

Question 2

What are the Nitrogen mustard drugs? MOA? Toxicities?

Answer 2

Cyclophosphamide and Ifosphosphamide..Crosslinking DNA.

Tox: Hemmhorrgic Cystic, Myelosuppression

Question 3

What are the Alkylsulfonates? MAO? Toxicities

Answer 3

Busulfan

Cross linking

Tox:

1. Pulmonary Fibrosis
2. Myelosuppression

Question 4

What are the Nitrosoureas?

Answer 4

Carmustine, Lomustine, Semustine, Streptsozin

Carmustine causes severe hangovers with Disulfuran

Question 5

Name the platinum drugs and their MOAs? and toxicities

Answer 5

Cisplatin and Carboplatin— DNA crosslinking.

EARS AND RENAL DAMAGE