EBV

Question 1

what are the physical properties of ebv

Answer 1

-enveloped
-icosahedral capsid
-200 nm in diameter
-dsdna 180 kb linear

Question 2

hodgkin’s lyphoma is caused by which virus and what are the co factors

Answer 2

ebv
genetic and enviromental

Question 3

burkitt’s lyphoma is caused by which virus and what are the co factors

Answer 3

ebv and malaria

Question 4

nasopharangeal cancer is caused by which virus and what are the co factors

Answer 4

ebv and immunodeficiency

Question 5

true or false ebv only infects t cells

Answer 5

wrongs, it is b cells aka resting B lymphocytes

Question 6

why is malaria a co factor

Answer 6

because malaria causes hypervariation and hyperproduction of antibodies

Question 7

where does the ebv virus replicates

Answer 7

oral epitheliam

Question 8

true or false: virus can come back

Answer 8

yes it can through the plasma cells found in the oral epithelium

Question 9

in which latency stage of ebv is nasopharyngeal carcinoma started

Answer 9

latency II

Question 10

in which latency stage of ebv is burkitt’s lynphoma started

Answer 10

latency I

Question 11

how does ebv cause cell proliferatyion

Answer 11

-LMP1 mimics cd40 in the nf-kb pathway which is I’m,portant for survival in cancer
- lmp2a mimics bcr which is important in the ras/pi3 kinase/akt pathway which is important for growth signaling