Ebola Flashcards
To pass this class.
Tell me about ebola’s structure.
In the filoviridae family. RNA virus with an unusual structure. Thread-like.
What is ebola’s mortality timeframe?
7-14 days after infection
What does EHF stand for?
Ebola Hemorrhagic Fever
What are the highly pathogenic subtypes of ebola?
Ebola-Zaire, Ebola-Sudan
When and where did the first ebola outbreak happen?
Between June and November 1976; Sudan and the Democratic Republic of the Congo
How is the ebola virus transmitted?
Direct contact with blood, organs, or other bodily fluids of infected persons
What are the three routes human-to-human transmission can occur?
- Close family contacts or caregivers in households
- Burial ceremonies where mourners have direct contact with the sick
- Transmission in hospital settings
What are hospital acquired infections of ebola called?
Nosocomial transmissions
What are the symptoms of ebola?
Fever, headache, joint and muscle aches, sore throat, weakness, diarrhea, vomiting and stomach pain, rash, red eyes, hiccups, internal and external bleeding
What does EVD stand for?
Ebola virus disease
Ebola infects ___ primarily in the liver.
Macrophages
Ebola infection in the liver may be the most important cause of ___ ___.
fluid loss
How does ebola cause mortality?
The pathogenesis of the virus is tied closely to triggering vigorous inflammation to the infection.
After infection, there is a period of markedly profound rapid viral replication.
What’s the immune response to ebola?
The adaptive immune response is activated; significant antibody responses from IgG. Passive transfer of IgG antibodies form people who recovered from Ebola was shown to be beneficial to people with active infection.
The new Ebola-VSV vaccine induces what protective antibodies?
IgG
