E2 Class Questions Flashcards
A patient with Parkinson’s disease is being treated with carbidopa-levodopa (Sinemet). The patient asks the nurse why he needs both agents. The nurse responds,
a. “The two medicines together are doubly effective.”
b. “This combination has fewer side effects.”
c. “You’ll tolerate this better than a single-agent medication.”
d. “The carbidopa helps the levodopa reach the brain.”
D. The carbidopa helps the levodopa reach the brain
Because of the side effects of levodopa and the fact that so much levodopa is metabolized before reaching the brain, an alternative drug, carbidopa, was developed to inhibit the enzyme dopa decarboxylase. By inhibiting the enzyme in the peripheral nervous system, levodopa reaches the brain. The carbidopa is combined with levodopa in a ratio of 1 part carbidopa to 10 parts levodopa
Which comment to the nurse indicates more teaching is needed for a patient taking carbidopa/levodopa?
a. “I know I need to take this drug once a day.”
b. “I know I shouldn’t stop taking this drug abruptly.”
c. “I understand my urine may become dark and discolored.”
d. “I know it may take a few weeks or months to control my symptoms.”
Answer: A “I know I need to take this drug once a day.”
Rationale: A statement from the patient such as “I know I need to take this drug once a day” indicates that more teaching is needed because carbidopa/levodopa has a short half-life and must be taken 3 or 4 times per day. The other answers are true.
NOTE: patients may start on a once-a-day dosing, but the frequency will increase up to 8 doses/day
Nursing interventions or patient education for Anti-Parkinson drugs
Nursing interventions:
Monitor for orthostatic hypotension
Administer drug with low-protein foods
High-protein foods interfere with drug transport to CNS
Taking with food can help reduce n/v
Monitor for signs of psychosis
Hallucinations, vivid dreams, paranoia
Do not abruptly discontinue
Warn of harmless brown discoloration of urine and sweat
Assess symptom status and “on-off” phenomenon
Monitor blood cell counts, liver and kidney function
All of the following are side effect/adverse effect of carbidopa/levodopa, except?
a. Postural hypotension
b. Decreased libido
c. Cardiac dysrhythmias
d. Dyskinesias
B. Decreased libido
Side effects/adverse reactions to Carbidopa/levodopa
Carbidopa-levadopa (Sinemet) Side effects:
Fatigue, insomnia
Dry mouth
Blurred vision
Orthostatic hypotension
Palpitations, dysrhythmias
Urinary retention
Nausea, vomiting
Dyskinesia, psychosis, severe depression
Hemolytic anemia, thrombocytopenia
Before administering carbidopa-levodopa (Sinemet) for the treatment of parkinsonism, it is most important for the nurse to assess the patient for a history of
a. pulmonary disease.
b. diabetes mellitus.
c. allergy to penicillin.
d. narrow-angle glaucoma.
Answer: D narrow-angle glaucoma
Rationale: Contraindications to therapy include narrow-angle glaucoma as dilating pupils increase pressure
Other contraindications: severe cardiac, renal, hepatic disease; and suspicious skin lesions (activates malignant melanoma).
Common side effects of anticholinergics in body systems (CNS, eyes, GI, Urinary, salivary glands)
CNS - confusion
Eyes – NOT to use with glaucoma (pupils dilate), blurry vision
GI – sluggish…constipation
Urinary – relaxed tone…retention
Salivary glands – dry mouth
A patient has been diagnosed with Alzheimer’s disease. The patient’s daughter asks the nurse what the cause of Alzheimer’s disease is. The best response by the nurse is “The cause of Alzheimer’s disease is
a. a virus
b. a cancer
c. unknown
d. normal aging
C. unknown
The cause of alzheimers is currently unknown
The nurse should teach the patient’s family to administer the medication rivastigmine (Exelon)
a. without food.
b with meals.
c. at 3:00 am and 3:00 pm.
d. when the patient is acting most confused.
B. Twice a day with food
Highest incidence of GI effects of any other drugs in this class
The patient’s daughter is with the nurse and is concerned about side effects of rivastigmine (Exelon).
What are the major side effects and what precautions or interventions can be done?
Rivastigmine (Exelon) Side effects:
Anorexia, nausea, vomiting, diarrhea, constipation, abdominal pain, dizziness, depression, peripheral edema
Has the highest incidence of GI effects of any other drugs in this class!
Adverse reactions: bradycardia, orthostatic hypotension, myocardial infarction, bronchoconstriction
Safety: prevent falls/fractures
The patient and her family want to know how the medication works. The nurse’s response would include which information? (Be sure to use terms that non-health care individuals can understand.)
The nurse will tell the patient that the medication will increase the level of a chemical in the brain, acetylcholine, allowing for better communication between cells involved in maintaining memory.
Rationale: Rivastigmine is an acetylcholinesterase inhibitor, which increases the amount of ACh at cholinergic synapses. AChE inhibitor
Used in patients with mild to moderate Alzheimer’s disease
Increases the amount of ACh at the cholinergic synapses
Potentially slows the disease process
The nurse is assessing an 8-year-old male patient who has a history of attention deficit hyperactivity disorder. The patient’s father notes that even though the child has been taking methylphenidate for 1 week, the child’s teacher still reports fidgeting and inattentiveness in class. The nurse notes that the patient is staring at his shoes and won’t look at her.
The patient’s father is concerned that the medication isn’t working. How will the nurse respond?
The nurse will explain that often the medication dosage is titrated to meet the individual needs of each patient. The nurse will let the father know that his concerns will be shared with the prescriber
Rationale: The dosage is often increased by 5 mg weekly until a desired effect or a maximum dose is reached.
ADHD peds case: The patient’s father wants to know the signs he should be looking for that the medication is having a therapeutic effect. What teaching will the nurse provide?
The nurse will advise the patient’s father that he should look for an improved attention span and/or improved ability to focus in the child. The father may also look for other signs, such as improving grades or fewer calls from the teacher.
Rationale: The medication is given to improve attention span and cognitive performance. decrease impulsiveness, hyperactivity, and restlessness
How does methylphenidate interact with caffeine?
Blood pressure medications?
How does methylphenidate interact with caffeine?
Potentiates amphetamine-like effect, may be fatal!
Blood pressure medications?
May decrease effect
Additionally, when taken with MAOIs - Risk of hypertensive crisis
Common Side Effects/Adverse reactions of methylphenidate
Tachycardia, palpitations, dizziness, hypertension
Sleeplessness, restlessness, nervousness, tremors, irritability
Increased hyperactivity
Anorexia, dry mouth, vomiting, diarrhea, weight loss
Thrombocytopenia
Important nursing interventions and patient education on methylphenidate?
Nursing interventions and patient education
Give with breakfast and lunch.
Report irregular heartbeat.
Record height, weight, and growth of children
Avoid alcohol, caffeine.
Use sugarless gum to relieve dry mouth.
Counseling must also be used.
What would indicate to the nurse that the child taking methylphenidate requires more teaching?
a. The child is seen drinking a cola product.
b. The child checks his weight twice a week.
c. The child takes the drug 45 minutes before a meal.
d. The child takes the drug before breakfast and lunch.
Answer: A. the child is seen drinking cola
Rationale: The nurse should teach the child to avoid caffeine because of its potentiation of methylphenidate.
The child should be checked twice a week for weight loss.
The drug should be taken before breakfast and lunch and not within 6 hours of sleeping.
Methylphenidate (Ritalin) should not be taken by patients with a history of which condition?
a. Renal failure
b. Cataracts
c. Hypothyroidism
d. Coronary artery disease
D. CAD
Rationale: Methylphenidate (Ritalin) is contraindicated in patients who have a history of heart disease, hypertension, hyperthyroidism, parkinsonism, or glaucoma.
When providing teaching to a group of parents regarding attention deficit/ hyperactivity disorder (ADHD), which information will the nurse include?
a. Children with ADHD have low intelligence.
b. Children with ADHD have an infection in their spinal fluid.
c. EEG results are typically normal in children with ADHD.
d. Learning disabilities are often present in the child who has ADHD.
D. learning disabilities often present in children with ADHD
Rationale: Intelligence is usually not affected by ADHD. The CSF of children with ADHD is not affected. Children with ADHD often have abnormal EEG studies. Children with ADHD often have learning disabilities.
Now that you know something about Doxapram, what is the difference between it and Narcan? Why is Narcan the first choice for opioid overdose?
Doxapram is a respiratory stimulant
Narcan is an antidote – blocks effect of opioid
A patient has been ordered a transdermal patch of methylphenidate (Ritalin). The nurse teaches the family to leave the patch on for how long?
a. 2 hours
b. 9 hours
c. 12 hours
d. 24 hours
B. 9 hours
Action of acetylcholinesterase inhibitor/cholinesterase inhibitors in relation to myasthenia gravis
Actions: Binds cholinesterase, not allowing the breakdown of ACh; transmission of neuromuscular impulses is allowed
Results in improved muscle strength and function