E Flashcards
– V1
agonist
• DOC for esophageal varicesQ
terlipressin
– V1
agonist
• DOC for esophageal varicesQ
terlipressin
– V2 agonist is
• DOC for neurogenic (central) diabetes
insipidus (Given by nasal route)Q
desmopressin
– V2 agonist is
• DOC for neurogenic (central) diabetes
insipidus (Given by nasal route)Q
desmopressin
Doc
Hypothyroidism
L-thyroxine (T4)
Hyperthyroidism
DOC in 1st trimester
PTU
Hyperthyroidism
Drug Can cause choanal
atresia and aplasia cutis
in developing fetus
Carbimazole (Prodrug)
Methimazole (Active)
Doc for T2 DM-Max. reduction in HbA1c
Metformin
Risk
- Lactic acidosis
Risk of lactic acidosis further ↑, if there isQ
– Liver disease (Gluconeogenesis cannot occur)
– Renal disease (Lactic acid produced cannot be
excreted)
– Any condition predisposing to hypoxia (e.g.;
Shock, COPD)
Thus, metformin is C/I in these patients
Hyperglycemia
Drug - Acarbose
c/l -
C/I in lnflammatory bowel diseaseQ
• Ulcerative colitis
• Crohn’s disease
Incretin
GLP-1 analogues : Used for type 2 DM
– Exenatide
– Liraglutide
GLP-2 analog : Used for short bowel syndrome
– Teduglutide
DPP - 4 inhibitors:
a. Sitagliptin
b. Vildagliptin
c. Alogliptin
d. Linagliptin
SGLT-2 Inhibitors
Drugs ?
Drugs are
– Canagliflozin
– Dapagliflozin
– Empagliflozin
– Ertugliflozin
Drug inhibit Osteoclasts
Bisphosphonates-
Alendronate
Risedronate
Zoledronate
– Inhibit osteoclasts
– DOC for Osteoporosis [Osteoporosis due to any
reason]
Used in post menupausal osteoporosis
– It is selective estrogen receptor modulator
– It has agonist action on ER in bone, blood and
liver whereas antagonistic action on breast and
endometrium
– Used in post menopausal osteoporosis
Raloxifene
DRUGS WITH DUAL ACTION
These have dual activity of stimulating
osteoblast and inhibiting osteoclast
– Strontium ranelate and romosozumab act by
dual mechanism
Ovulation inducers are used to induce ovulation
• Aromatase inhibitors e.g. letrozole is DOC
• Clomiphene citrate can also be used.
