Autocoids Flashcards
H3 Inverse
Agonist
Tiprolisant
[Pitolisant]
Used for
Narcolepsy
Monoclonal Antibodies Against CGRP
• Approved for prophylaxis of migraine.
• Given by injectable route.
– Erenumab
– Fremanezumab
– Galcanezumab
– Eptinezumab
CGRP Antagonist: (GEPANTS)Q
• Used for acute attack
• Effective orally
• Drugs are
– Olcegepant
– Rimegepant
– Ubrogepant
PDA [Patent ductus Arteriosus] is treated by
NSAIDs like
– Aspirin
– Indomethacin
– Ibuprofen (DOC)
Used for abortion
Misoprostol
DOC for Primary Open Angle GlaucomaQ
Latanoprost
NSAID
Selective COX 2 Inhibitors
Drugs
- Celecoxib
- Rofecoxib
Valdecoxib - Parecoxib
- Lumiracoxib
GOUT
DOC
: NSAIDs -except
aspirin and paracetamol
Acute Gout
-Colchicine (Most effective drug):Q
Cause ?
- Can cause myopathy and diarrhea
- Inhibit granulocyte migration
• Inhibit xanthine oxidase
• DOC for chronic gout
Allopurinol
.↑ Metabolism of Uric acid and These are fastest urate lowering agents for tumor
lysis syndromeQ
Rasburicase → Recombinant uricase
Pegloticase
→ Long acting uricase
Fastest acting DMARD
Leflunomide
DOC for ulcerative
colitis
Sulfasalazine
Biological DMARDs:
Drugs Inhibiting TNF-a:Q
- All are injectable
A Adalimumab
C Certolizumab
E Etanercept
Inhibitor lnfliximab
Goli Golimumab
→ ↑ Risk of infections.
→ Contra-indicated in T.B. and Hepatitis B
→ Apart from R.A., these drugs can be used for Crohn’s
disease as well as Psoriasis
DMARD
IL - 1 Receptor Antagonist:Q
i
ANAKINRA
IL - 6 Receptor Antagonists:Q
Tocilizumab
