Dyslipidemia Therapy Drugs

Question 2

Statins

Answer 2

decrease LDL, not good for isolated high TG
side effects: myopathy, rhabdomyolysis, headache

Question 3

Omega-3 ethyl esters

Answer 3

dosing varies (1-2x daily), can cause prolonged bleeding, impaired platelet function/production

Question 4

Gemfibrozil

Answer 4

inhibits cholesterol synthesis
Decreases: TC, LDL, TG**
Increases: HDL
600mg bid
side effects: nausea, diarrhea, cholelithiasis, phototoxicity
Interactions: statins, niacin

Question 5

Fenofibrate

Answer 5

inhibition of cholesterol synthesis
DECREASES: TG and LDL
INCREASES: LPL and HDL
dosing varies
can cause: nausea, diarrhea, cholelithiasis, phototoxicity
Interactions: statins, niacin

Question 6

Ezetimibe

Answer 6

cholesterol absorption inhibitor
decrease LDL increase HDL
10mg/day
minimal drug interactions and effect on TG

Question 7

What are the gold standard drugs for lowering LDL?

Answer 7

statins