Duchenne Muscular Dystrophy

Question 1

etiology of DMD

Answer 1

inherited in an x-linked recessive pattern
- mutated gene on x chromosome from mother

Question 2

define DMD

Answer 2

Genetic neuromuscular condition characterized by progressive muscle weakness and contractures

Question 3

what causes DMD

Answer 3

absence of dystrophin protein
– maintains muscle integrity

Question 4

s/s of DMD

Answer 4

pseudohypertrophy due to fat and connective tissue build up

muscle weakness

cognitive impairments / respiratory decline

Question 5

ages significant with DMD

Answer 5

1-6 y/o = muscle weakness
6-11 y/o = progressive decline
10 y/o = respiratory decline/cardiomyopathy
13 = full wheelchair use
20’s = life expectancy

Question 6

primary interventions for those with DMD

Answer 6

anticipatory/preventative measures
stretching
submax aerobic exercise
strength training
pharmacological
surgery if indicated

Question 7

assistive technology for those with DMD

Answer 7

AFO = night, for contracture prevention
KAFO = late ambulatory, non-ambulatory phase
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