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EBM > DTA > Flashcards

DTA Flashcards

1
Q

What is a diagnostic test accuracy study

A

Study that looks at how well a test identifies or rules out a disease (sensitivity and specificity)

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2
Q

What is the importance of DTA study

A

To see if a new test is useful or harmful

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3
Q

What question do we use in DTA instead of an PICO

A

PITR

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4
Q

What does PITR stand for

A

Patient
Index test
Target disorder
Reference standard

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5
Q

What is an index test

A

The test that we are interested in testing

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6
Q

What is a reference standard

A

The test that is most accurate

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7
Q

What are the types of errors that can occur in a diagnostic test

A

False positive

False negative

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8
Q

What is a false positive

A

Someone that does not have the disease presents as having it

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9
Q

What is a false negative

A

Someone that has the disease presents as not having the disease

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10
Q

What is the formula for sensitivity

A

TP/(TP+FN)

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11
Q

What is the formula for specificity

A

TN/(TN+FP)

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12
Q

What is sensitivity good at

A

Ruling out conditions

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13
Q

What is a high specificity good at

A

Ruling in conditions

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14
Q

What are the 3 types of bias that can occur in a DTA study

A

Spectrum bias
Review bias
Verification bias

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15
Q

What is spectrum bias

A

People that have diseases that are hard to diagnose have been excluded out of the study

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16
Q

What is review bias

A

The index test is not blind to the reference standard and vice versa

17
Q

What is verification bias

A

When patients do not receive both index test and reference standard so this leads to under and over estimation

18
Q

What are the disadvantages of a bad diagnostic test

A

Over treatment

Unnecessary anxiety and pain of procedure

19
Q

What questions do you need to think about to apply the result of a DTA study to your patients and setting?

A
  • was there a clear study question
  • is the study population spectrum similar to patients in practise
  • can the index test be applied in the same way in your healthcare setting
  • does the target condition match the condition you want to identify

EBM (3 decks)

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