Drugs Toxins Chemical Agents

Question 1

tetanus toxin is a ______ dependent protease

Answer 1

zinc

Question 2

mode of action tetanus toxin

Answer 2

blocks neurotransmitter release by cleaving surface proteins of synaptic vesicles, preventing exocytosis of neurotransmitter

blockade of inhibitory neurotransmitters mainly GABA at presynaptic sites in spinal cord and brainstem

Question 3

Tetanus. Most common form

Answer 3

Generalized

Question 4

generalized tetanus

this is the most frequent first manifestation

Answer 4

trismus

Question 5

most benign form of tetanus

Answer 5

local tetanus

Question 6

mortality rate in tetanus

Answer 6

50%