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Pharmacology > Drugs to tx hyperlipidemia > Flashcards

Drugs to tx hyperlipidemia Flashcards

1
Q

Group #2 Drugs

A

Ezetimibe

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2
Q

Group #3 HMG Reductase Inhibitors

A
  • Lovastatin
  • Simvastatin
  • Pravastatin
  • Fluvastatin
  • Atorvastatin
  • Rosuvastatin
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3
Q

Group #4 Fibric Acid Derivatives

A
  • Gemfibrozil
  • Fenofibrate
  • Clofibrate
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4
Q

Group #5

A

Niacin

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5
Q

Group #1 Side Effects

A
  • Constipation

* Impede absorption of fat soluble vitamins

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6
Q

Group #2 Side Effects

A

[] Fatigue

[] Stomach Pain

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7
Q

Group #3 Side Effects

A

[] ^ hepatic enzyme levels
[] Myopathy
[] Rhabdomyolysis (muscle degradation - creatine kinase ^ in blood & breaks down muscle)
[] Hepatotoxicity = ^ in liver enzymes

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8
Q

Group #4 Side Effects

A

[] Gallstone formation

[] Slight risk of liver cancer

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9
Q

Group #5 Side Effects

A 
[] Cutaneous Flush
[] Liver toxicity
[] Hyperglycemia
[] Hyperurecemia (can cause gout)
[] Nausea and Vomiting
[] Diarrhea
[] ^ Levels of homocysteine which ^ risk of coronary heart disease
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10
Q

Causes of Hyperlipidemia?

A
  1. Genetic

2. Metabolic Disorders

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11
Q

What gives rise to primary lipidemia?

A

Genetic disorders

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12
Q

What metabolic disorders give rise to secondary lipidemia?

A
  • Renal disease
  • Hypothyroidism
  • Alcoholism
  • Diabetes
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13
Q

Name the lipoproteins in the blood?

A
  1. Chylomicrons
  2. VLDL
  3. LDL
  4. HDL
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14
Q

Action of Chylomicrons?

A

Transports dietary triglycerides, cholesterol, fat soluble vitamins, cholesterol esters to peripheral tissues.

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15
Q

Action of VLDL?

A

Carries triglycerides from liver to peripheral tissues (adipose tissue, cardiac, skeletal muscle) can be used as storage or energy source.

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16
Q

Action of LDL?

A

Transports cholesterol to peripheral tissues as well as back to the liver.

17
Q

Action of HDL?

A

Transports cholesterol from peripheral tissues to liver for bile acid synthesis, or for disposal via bile, as well as to steroidalgenic cells for steroid synthesis.

18
Q

1st action to tx lipidemia?

A

Diet & Exercise

19
Q

2nd action to tx hyperlipidemia?

A

Decrease bile & cholesterol absorption from GI tract, group #1 & #2 drugs to tx this.

20
Q

3rd action to tx hyperlipidemia?

A

decrease cholesterol synthesis by liver, drug from group #3

21
Q

4th action to tx hyperlipidemia?

A

^ peripheral clearance of lipoproteins, drug from group #4

22
Q

5th action to tx hyperlipidemia?

A

decrease secretion of hepatic VLDL’s, group #5 drugs.

23
Q

Drug combinations

A
  • Simvastatin/Ezetimibe
  • Niacin/Lovastatin
  • Atorvastatin/Amlodipine
24
Q

Group #1 Bile Acid-Binding Resins Drugs

A
  • Cholestyramine
  • Colestipol
  • Colesevelem Welchol

Pharmacology (8 decks)

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