Drugs that interact with statins Flashcards by Jeri Sheldon (AZ PA Mast 20) | Brainscape

Q

Macrolides, esp erythromycin

A

P450 inhibitors

Increases plasma concentration of statins

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Q

How is ezetimibe therapy given?

A

only in combination with statins: synergistic

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Q

Ritonavir

A

P450 inhibitor

Increases plasma concentration of statins

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Q

Rifampin

A

P450 activator

Decreases plasma concentration of statins

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Q

Gemfibrozil (fibric acid derivative) drug interaction

A

Inhibits metabolism of statins

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Q

Barbiturates

A

P450 activator

Decreases plasma concentration of statins

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Q

Verapamil

A

P450 inhibitor

Increases plasma concentration of statins

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Q

Grapefruit juice

A

P450 inhibitor

Increases plasma concentration of statins

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Q

Griseofulvin

A

P450 activator

Decreases plasma concentration of statins

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Q

Ketoconazole

A

P450 inhibitor

Increases plasma concentration of statins

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Q

Phenytoin

A

P450 activator

Decreases plasma concentration of statins

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Q

Who can’t take statins?

A

Pregnant

Hepatic disease

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Q

Cyclosporine

A

P450 inhibitor

Increases plasma concentration of statins

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