Drugs Q2

Question 1

Selectively binds to the beta subunits of prokaryotic RNA pol, preventing txn elongation.
Does not affect eukaryotic RNA pol.
Treats bacterial infections such as tuberculosis and leprosy; often used in a cocktail due to resistance.

Answer 1

Rifampicin

Question 2

Antibiotic that binds to DNA at txn initiation complex and prevents elongation by RNA pol.

Answer 2

Actinomycin D

Question 3

Bacterial antibiotic that blocks binding of aminoacyl-tRNA to A site of ribosome.

Answer 3

Tetracycline

Question 4

Bacterial antibiotic that prevents the transition from translation initiation to chain elongation and also causes miscoding (alters the structure of 30S subunit)

Answer 4

Streptomycin

Question 5

Bacterial antibiotic that blocks the peptidyl transferase rxn on 50S subunit of ribosome, preventing peptide bond formation.

Answer 5

Chloramphenicol

Question 6

Bacterial antibiotic that binds in the exit channel of the 50S ribosome and thereby inhibits elongation of the peptide chain.

Answer 6

Erythromycin

Question 7

Bacterial antibiotic that blocks initiation of RNA chains by binding to RNA pol (preventing RNA synthesis = transcription)

Answer 7

Rifamycin

Question 8

Bacterial and eukaryotic antibiotic that causes the premature release of nascent polypeptide chain by its addition to the growing chain end.

Answer 8

Puromycin

Question 9

Eukaryotic antibiotic that blocks the translation reaction on ribosomes.

Answer 9

Cycloheximide

Question 10

Eukaryotic antibiotic that blocks mRNA synthesis by binding preferentially to RNA pol II.

Answer 10

Alpha amanitin