Drugs Q2 Flashcards
Does rifampicin prevent transcription or translation?
Blocks prokaryotic transcription elongation
Rifampicin binds to and inhibits this enzyme
Prokaryotic RNA pol
Prevents transcription elongation
Does Actinomycin D block transcription or translation?
Transcription (prevents elongation by RNA pol)
Bacterial antibiotic that blocks binding of aminoacyl-tRNA to A site of ribosome.
Tetracycline
Does tetracycline block transcription or translation?
Translation (blocks aminoacyl-tRNA binding to A site of ribosome)
Bacterial antibiotic that prevents the transition from translation initiation to chain elongation and also causes miscoding (alters the structure of 30S subunit)
Streptomycin
Does streptomycin block transcription or translation?
Translation (binds 30S ribosome)
Does chloramphenicol block transcription or translation?
Translation (binds 50S ribosome)
Bacterial antibiotic that blocks the peptidyl transferase rxn on 50S subunit of ribosome, preventing peptide bond formation.
Chloramphenicol
Does erythromycin block transcription or translation?
Translation (binds 50S ribosome)
Bacterial antibiotic that binds in the exit channel of the 50S ribosome and thereby inhibits elongation of the peptide chain.
Erythromycin
Bacterial antibiotic that blocks initiation of RNA chains by binding to RNA pol (preventing RNA synthesis = transcription)
Rifamycin
Does rifamycin block transcription or translation?
Transcription (binds RNA pol)
Bacterial and eukaryotic antibiotic that causes the premature release of nascent polypeptide chain by its addition to the growing chain end.
Puromycin
Does cycloheximide block transcription or translation?
Translation
