Compounds Q6

Question 1

Phenyl butyrate and benzoic acid are treatment for this

Answer 1

Hyperammonemia

Question 2

Niacin in large doses can be used to treat this

Answer 2

Hyperlipidemia

Question 3

Sulfa drugs competitively inhibit steps in purine synthesis in bacteria that require this

Answer 3

Folate

Question 4

Methotrexate inhibits this enzyme

Answer 4

Dihydrofolate reductase

Question 5

Trimethoprim inhibits this

Answer 5

Dihydrofolate reductase

Question 6

Vanillyl mandelic acid is an excreted product of these

Answer 6

Catecholamines

Question 7

This is measured to determine activity of adrenal production of catecholamines

Answer 7

Vanillyl mandelic acid

Question 8

Tyramine is normally degraded by this enzyme

Answer 8

Monoamine oxidase (MOA)

Question 9

Amine which displaces norepinephrine from storage vesicles
Made from tyrosine in the decarboxylation of wines and cheeses

Answer 9

Tyramine

Question 10

Antidepressants may inhibit this enzyme
Makes patients sensitive to tyramine rich foods

Answer 10

Monoamine oxidase

Question 11

Allopurinol inhibits this enzyme

Answer 11

Xanthine oxidase

Question 12

Febuxostat inhibits this enzyme

Answer 12

Xanthine oxidase

Question 13

Allopurinol and Febuxostate inhibit xanthine oxidase, thus blocking the production of this

Answer 13

Uric acid

Question 14

Probenecid increases excretion of this

Answer 14

Uric acid

Question 15

Molecule missing in humans that degrades uric acid to soluble allantoin

Answer 15

Uricase

Question 16

5-fluorouracil inhibits this enzyme

Answer 16

Thymidylate synthase

Question 17

Glutamine analog that is used as an antineoplastic drug
Inhibits glutamine PRPP amidotransferase, CPS II, and CTP synthase

Answer 17

Azaserine

Question 18

Compound used in the synthesis of plastics that can cause angiosarcoma in the liver if not properly metabolized and excreted

Answer 18

Vinyl chloride

Question 19

CYP that metabolizes vinyl chloride to an epoxide which causes DNA damage

Answer 19

CYP 2E1

Question 20

Mold product that is metabolized by CYP 2A1 to a compound producing liver cancer

Answer 20

Aflatoxin

Question 21

Aflatoxin is metabolized to a compound producing liver cancer by this CYP

Answer 21

CYP 2A1

Question 22

Compound that is metabolized by P450s to an epoxide that reacts with DNA guanine residues, disrupting GC base pairs and leading to lung cancer

Answer 22

Benzopyrene

Question 23

Theophylline, HIV protease inhibitors, Warfarin, SSRIs, oral contraceptives, chemotherapy, and simvastatin/atorvastatin are metabolized by this CYP

Answer 23

CYP 3A4

Question 24

Compound that induces CYP 3A4 and decreases its efficacy in metabolizing many drugs

Answer 24

St. John’s Wort

Question 25

St. John's Wort may induce this CYP

Answer 25

CYP 3A4

Question 26

Antidote to acetaminophen poisoning that stimulate glutathione synthesis

Answer 26

N-Acetyl-Cysteine

Question 27

N-acetyl-cysteine stimulates the synthesis of this

Answer 27

Glutathione

Question 28

Toxin produced when ethanol induces CYP 2E1 pathway for acetaminophen disposal

Answer 28

NAPQI

Question 29

NAPQI is disposed of by using this molecule which becomes depleted with large doses of tylenol

Answer 29

Glutathione

Question 30

Antabuse inhibits this enzyme

Answer 30

ALDH

Question 31

Antabuse is used for this

Answer 31

Limits drinking

Question 32

ALDH releases NO from this

Answer 32

Nitroglycerin