DRUGS on ANS Flashcards
1
Q
M1
A
Gq (ip3/dag, pla2)
2
Q
M2
A
Gi/Go (K opening, cAMP decrease/ Ca channel opening)
3
Q
M3
A
Gq (ip3/dag, pla2)
4
Q
muscarinic action
A
hyperpolarise SA node
av node and Purkinje fibers - increase refractory period
atrial contractility decreased
nonuniform vagal innervation - fibrillation, flutter
vasodilation M3 (Gq- Ca-Cal- NO) + Erection
contraction of muscle
relaxation of sphincter
secretion increased M3, M2
MIOSIS
5
Q
nictonic actions
A
ans ganglia stimulated at higher dose - sympathetic stimulation
contractions of sk ms
6
Q
bethanechol
A
nonobstructive urinary retention, neurogenic bladder
7
Q
Ach esterase function
A
ganglia stimulation cvs - para and sympathetic - variation sk muscle - twitching fasiculations cns- alerting other ACH effects
8
Q
physostigmine
A
eye drops
9
Q
pyridostigmine
A
myasthenia gravis
