CVS Flashcards
1
Q
Captopril
A
ACE inhibitor inhibits Ang I conversion to Ang II vasoconstriction no reflex sympathetic stimulation splits off a dipeptidyl segment from - ACE, bradykinnin, substance P, stem cell regulator peptide feedback increase in renin Ang I is diverted to Ang 1-7 ADR: hypotension, hyperkalameia, cough, rahses, angioedema, dysgeuisia, airway obstruction, foetopathy, granulocytopenia and proteinuria, ac. renal failure (in pt with bilateral renal artery stenosis)
2
Q
kinnins
A
acute vasopressor
cough
angioedema
3
Q
stem cell regulator peptide
A
cardioprotective
4
Q
greater fall in BP by captopril
A
when Na has been depleted
CHF
renovascular, accelerated and malignant hypertension
5
Q
Captopril pk
A
70% oral food reduce absorption excretion in urine half life- 2 hour action - 12 hours
6
Q
food reduce absorption of all ace inhibtors except
A
enaliprilat, trandolapril (only delayed)
7
Q
enalapril
A
desterified into enaliprilat, injectable more potent slow onset longer duration
8
Q
lisinopril
A
lysine deravative of enalprilat oral slow absorption, incomplete duration longer decrease in vr, and co
9
Q
perindopril
A
long acting slow onset 20% perindoprilat extensive metabolism
10
Q
fosinopril
A
phosphinate
glucuronide conjugated
liver, urine - elimination
11
Q
First dose hypotension
A
fosinopril
12
Q
Ramipril
A
extensive tissue distribution- bound drug
8-18 hours- t half life
13
Q
quinapril
A
prodrug carboxyl - quinaprilat
bound to tissue
elimination urine, bile
14
Q
biphasic half life
A
quinapril - 2- 24 hours
trandolapril - 10-24 hrs
15
Q
trandolapril
A
carboxyl prodrug
40-60%
eliminated urine, faeces
