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Psychiatry > Drugs of Abuse (4-16-14) > Flashcards

Drugs of Abuse (4-16-14) Flashcards

1
Q

signs of opioid intoxication

A 
MIOSIS
N/V
respiratory depression
altered mental status 
nods
euphoria
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2
Q

sings of opioid withdrawal

A 
MYDRIASIS
shaking
N/V
cramps
insomnia
agitation & anxiety
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3
Q

methadone: what’s it used for? MOA? How much do you give?

A

substitution therapy for opiods
long-acting opiod agonist
30mg can prevent withdrawal
never give >30mg initially –> death!

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4
Q

Naltrexone: what’s it used for? MOA?

A

Rx to stop opioid use
mu antagonist
orally bioavaiable; takes a while to get into system (don’t use in ER)

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5
Q

Naloxone: what’s it used for? MOA?

A

Rx to stop opioid use
mu antagonist
give IV or IM (ER)

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6
Q

Suboxone: what’s it used for? MOA?

A

Rx to stop opioid use
partial opiod agonist + kappa-antagonist
more docs can prescribe, less strict than methadone

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7
Q

Clonidine: what’s it used for? MOA?

A 
Rx to stop opioid use
alpha-2 agonist
HTN medication 
prevents sympathetic effects that come w/ withdrawal 
don't use long term
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8
Q

Cocaine: signs of intoxication? What drugs do you not give with this?

A 
MYDRIASIS
tachycardia 
psychotic-like symptoms --> TACTILE HALLUCINATION = FORMICATION = ants crawling on you 
a-vasoconstriction --> MI/Stroke/HTN
never give w/ beta blockers
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9
Q

Treatment for Cocaine?

A

abstinence

no meds work

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10
Q

PCP: MOA?

A

antagonizes NMDA

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11
Q

PCP: Signs of intoxication?

A

ROTARY NYSTAGMUS = pathognomic
seizures
superhuman strength
aggressive

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12
Q

What disease does PCP emulate?

A

schizophrenia

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13
Q

What disease does Cocaine emulate?

A

mania

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14
Q

Cannabis: MOA?

A

binds cannabinoid receptors
CB1 (brain
CB2
THC = neuroactive substance in marijuana –> partial agonist of CB1

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15
Q

Cannabis: Signs of intoxication?

A 
CONJUNCTIVAL INJECTION
psychosis
lazy
visual hallucinations
altered perception of time
anxiety symptoms
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16
Q

Cannabis: Signs of withdrawal?

A

anxiety

headaches

17
Q

Cannabis: treatments?

A

none

18
Q

Synthetic Cannabis: MOA? How much stronger than regular cannabis? Symptoms?

A

full agonist CB1 receptors
600-800x more potent than marijuana
lots of psychosis! 20-30% psychosis

19
Q

Ecstacy/Molly: MOA?

A

Molly = Molecular MDMA

increases serotonin

20
Q

Ecstacy/Molly: signs of intoxication?

A

hyperthermia! That girl Molly is hot!

21
Q

Bath salts: signs of toxicity?

A

psychosis

violently agitated

22
Q

Bath salts: what’s in them?

A

Amphetamines + MDMA = incr Dopamine, NE, Serotonin

23
Q

LSD: MOA? SE? Toxicity? withdrawal?

A 
increase serotonin
Hallucinogen
persistent psychotic state
develop tolerance easily 
no withdrawal state
24
Q

Krokodile

A

Desomorphine = short-acting morphine

causes degeneration of skin

Psychiatry (10 decks)

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