drugs of abuse

Question 1

Illegal sedatives
CNS depressants
interfere with memory
“date rape” drugs

Answer 1

GHB
Royhypnol

*Royhypnol can be used at low dose for narcolepsy

Question 2

psychedelics
distort perception: hallucinations, illusions
dissociative drugs
MOA: NMDA antagonists leading to disinhibition of excitatory pathways

Answer 2

PCP
ketamine
dextromethorphan (opioid antitussive)

Question 3

psychedelics
MOA: 5-HT2 and 5-HT1a receptor agonist
-increases glutamate at the cortex

Answer 3

LSD
mescaline
psilocybin

Question 4

Psychedelic
MOA: increases release of 5-HT via transport reversal
Adverse: hyperthermia spurs excessive water drinking: hyponatremia, seizures and death

Answer 4

MDMA (Ecstasy)

Question 5

binds to cannabinoid receptors

THC causes disinhibition of GABA neurons of VTA resulting in euphoria & relaxation

Answer 5

marijuana

Question 6

produces euphoria and sedation via activation of mu receptors

Answer 6

morphine

heroin

Question 7

agonist of nACh receptor in the VTA causing release of dopamine to the nucleus accumbens and prefrontal cortex
highly addictive

Answer 7

nicotine

Question 8

dopamine neurons of VTA become activated in anticipation of reward

Answer 8

addiction