Drugs of abuse Flashcards
On what receptor do Cannabinoids act and what is the effect?
CB1, inhibition of glutamate release
On what receptor does GHB act
GABA-B
On what receptor does LSD act?
5HT2A
On what receptor does nicotine act and what is the effect?
Selective nAChR agonist, rewarding effects are governed by the control of release of fopamine in the prefrontal cortex and nucleus accumbens
On what receptor do ketamine and phencyclidine act?
Non competetive NMDA antagonists, anesthetic effect.
On what receptor do amphetamines act?
They are a substrate for dopamine transporter (DAT),. They inhibit the vesicle fillinf through VMAT, which leads to more intracellular dopamine which gets exported through DAT. Result is more dopamine in synaptic cleft.
On what receptor does MDMA act?
MDMA is a serotonin transporter substrate
On what receptor does Cocaine act?
NET blocker
