Drugs & MOA

Question 1

Inhibition of cell wall synthesis

- binds to enzyme that forms protein cross linkages

Answer 1

Penicillins
Amoxicillin
Methicillin (Meticillin)
Ampicillin
Augmentin (penicillin + clavulanic acid)

Cephalosporins
Cef -
Ceph-

Carbapenems
Imipenem (Primaxin)

Question 2

Inhibition of cell wall synthesis

- inhibits synthesis of glycan strands

Answer 2

Bacitracin

Question 3

Inhibition of cell wall synthesis

- binds to glycan strands to prevent cross linking

Answer 3

Glycopeptides (Vancomycin)

Question 4

Inhibition of DNA replication

- targets DNA unwinding enzyme

Answer 4

Quinolones

• Nalidixic Acid
• Cipro
• Levaquin

Question 5

Inhibition of Protein Synthesis - transcription

- targets RNA polymerase

Answer 5

Rifmycins

- Rifampin

Question 6

Inhibition of protein synthesis - translation (targets ribosomes)

Answer 6

Amioglycosides

• Streptomycin
• Neomycin
• Tobramycin
• Gentamycin Sulfate

Tetracyclines

• Sumycin
• Doxycycline

Chloramphenicol

Macrolides

• Erythromycin
• Clarithromycin (Clarem)
• Azitrhomycin (Zithromax = Zpac)

Lincosmide (Clindamycin)

Question 7

Molecular mimicry

- blocks PABA from binding to enzyme to block folic acid synthesis

Answer 7

Sulfonamides or Sulfa drugs

• Bactrim
• Septra

Question 8

Inhibition of DNA replication

- reduced drug taken up; makes DNA unstable

Answer 8

Metronidazole

- Flagyl