Drugs interfering w/ NT synth Flashcards

p67

1
Q

What drug inhibits dihydroorotate DH?

A

Leflunomide

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2
Q

What 2 drugs inhibit IMP DH?

A

Mycophenolate

Ribavirin

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3
Q

What drug inhibits ribonucleotide reductase?

A

Hydroxyurea

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4
Q

What 2 drugs inhibit de novo purine synthesis?

A

6-MP

Azathioprine (prodrug of 6MP)

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5
Q

What drug inhibits thymidylate synthase?

A

5-FU

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6
Q

What 3 drugs inhibit dihydrofolate reductase?

A

Methotrexate, trimethoprim, pyrimethamine

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