Drugs in the Synapse and other Things Flashcards
What is the function of Monoamineoxidase (MAO) enzymes?
Breaks down and metabolizes monoamine neurotransmitters
What is caused by prolonged deprivation of agonist drugs
Up regulation
What is the function of a negative allosteric modulator?
Modifies and restricts the channel of a receptor
What type of drug prevents metabolism?
MAO/Enzyme Inhibitor
What is caused by the chronic use of agonist drugs?
Down regulation
What type of drug blocks the site where the neurotransmitter binds to the receptor?
Competitive Antagonist
What type of drug modifies and restricts the channel of the receptor?
Negative Allosteric Modulator
What is down regulation?
A decrease in the total number of receptors?
What is the function of an Antagonist Drug?
Blocks neurotransmitters from binding to receptors
What is a VMAT’s function?
Carries Neurotransmitters into vesicle
When a drug passes through the blood brain barrier it can_______
Work in the brain (be Psychoactive)
Tryptophan is a precursor molecule for what neurotransmitter?
5HT/Serotonin
What carries Neurotransmitters into vesicles?
VMAT
What is up regulation?
An Increase in the total number of receptors?
What type of drug mimics neurotransmitters
Agonist Drug
What is the precursor molecule for epinephrine?
Tyrosine
What type of drug blocks neurotransmitters from binding to receptors?
Antagonist Drug
What is the precursor molecule for 5HT/Serotonin
Tryptophan
What is the function of a non-competitive antagonist Drug?
Blocks neurotransmitters from inside the channel of the receptor
What is the function of a reuptake inhibitor?
Blocks the membrane transporter–Prevents the process of Reuptake–prevents neurotransmitters from being absorbed into the presynaptic neuron
What is the function of a positive allosteric modulator?
Modifies and inflates the channel of a receptor
What is the precursor molecule for Dopamine?
Tyrosine
What is the process of absorbing secreted neurotransmitters back into the presynaptic neuron called?
Reuptake
Tyrosine is the precursor molecule for what neurotransmitter?
Dopamine, Epinephrine, Norepinephrine
What is Reuptake?
The process of absorbing secreted neurotransmitters back into the presynaptic neuron
What type of drug blocks the membrane transporter/prevents neurotransmitters from being absorbed into the presynaptic neuron?
Reuptake inhibitor
What type of drug modifies and inflates the channel of a receptor?
Positive Allosteric Modulator
For a drug to work in the brain (be psychoactive) what must be true?
It must pass through the blood brain barrier
What breaks down and metabolizes monoamine neurotransmitters?
Monoamineoxidase (MAO) enzymes
What is the precursor molecule for Norepinephrine?
Tyrosine
What is the function of an allosteric modulator?
Changes the shape of the receptor
What is the function of MAO/Enzyme Inhibitor?
Prevents Metabolism
What is the function of a competitive antagonist Drug?
Blocks neurotransmitters from binding to receptors by blocking the site where they bind to the receptor.
What is the function of an Agonist Drug?
Mimics the neurotransmitter
What is a VMAT?
Vesicle Monoamine Transporter
What is caused by the chronic use of antagonist drugs?
Up regulation
What type of drug changes the shape of the receptor?
Allosteric modulator
What is the name of the process for the decrease in the total number of receptors?
Down Regulation
What type of drug functions by blocking the neurotransmitter from the inside of the channel of the receptor?
Non-competitive antagonist
