Drugs in the Synapse and other Things Flashcards

(39 cards)

1
Q

What is the function of Monoamineoxidase (MAO) enzymes?

A

Breaks down and metabolizes monoamine neurotransmitters

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2
Q

What is caused by prolonged deprivation of agonist drugs

A

Up regulation

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3
Q

What is the function of a negative allosteric modulator?

A

Modifies and restricts the channel of a receptor

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4
Q

What type of drug prevents metabolism?

A

MAO/Enzyme Inhibitor

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5
Q

What is caused by the chronic use of agonist drugs?

A

Down regulation

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6
Q

What type of drug blocks the site where the neurotransmitter binds to the receptor?

A

Competitive Antagonist

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7
Q

What type of drug modifies and restricts the channel of the receptor?

A

Negative Allosteric Modulator

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8
Q

What is down regulation?

A

A decrease in the total number of receptors?

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9
Q

What is the function of an Antagonist Drug?

A

Blocks neurotransmitters from binding to receptors

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10
Q

What is a VMAT’s function?

A

Carries Neurotransmitters into vesicle

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11
Q

When a drug passes through the blood brain barrier it can_______

A

Work in the brain (be Psychoactive)

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12
Q

Tryptophan is a precursor molecule for what neurotransmitter?

A

5HT/Serotonin

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13
Q

What carries Neurotransmitters into vesicles?

A

VMAT

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14
Q

What is up regulation?

A

An Increase in the total number of receptors?

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15
Q

What type of drug mimics neurotransmitters

A

Agonist Drug

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16
Q

What is the precursor molecule for epinephrine?

17
Q

What type of drug blocks neurotransmitters from binding to receptors?

A

Antagonist Drug

18
Q

What is the precursor molecule for 5HT/Serotonin

19
Q

What is the function of a non-competitive antagonist Drug?

A

Blocks neurotransmitters from inside the channel of the receptor

20
Q

What is the function of a reuptake inhibitor?

A

Blocks the membrane transporter–Prevents the process of Reuptake–prevents neurotransmitters from being absorbed into the presynaptic neuron

21
Q

What is the function of a positive allosteric modulator?

A

Modifies and inflates the channel of a receptor

22
Q

What is the precursor molecule for Dopamine?

23
Q

What is the process of absorbing secreted neurotransmitters back into the presynaptic neuron called?

24
Q

Tyrosine is the precursor molecule for what neurotransmitter?

A

Dopamine, Epinephrine, Norepinephrine

25
What is Reuptake?
The process of absorbing secreted neurotransmitters back into the presynaptic neuron
26
What type of drug blocks the membrane transporter/prevents neurotransmitters from being absorbed into the presynaptic neuron?
Reuptake inhibitor
27
What type of drug modifies and inflates the channel of a receptor?
Positive Allosteric Modulator
28
For a drug to work in the brain (be psychoactive) what must be true?
It must pass through the blood brain barrier
29
What breaks down and metabolizes monoamine neurotransmitters?
Monoamineoxidase (MAO) enzymes
30
What is the precursor molecule for Norepinephrine?
Tyrosine
31
What is the function of an allosteric modulator?
Changes the shape of the receptor
32
What is the function of MAO/Enzyme Inhibitor?
Prevents Metabolism
33
What is the function of a competitive antagonist Drug?
Blocks neurotransmitters from binding to receptors by blocking the site where they bind to the receptor.
34
What is the function of an Agonist Drug?
Mimics the neurotransmitter
35
What is a VMAT?
Vesicle Monoamine Transporter
36
What is caused by the chronic use of antagonist drugs?
Up regulation
37
What type of drug changes the shape of the receptor?
Allosteric modulator
38
What is the name of the process for the decrease in the total number of receptors?
Down Regulation
39
What type of drug functions by blocking the neurotransmitter from the inside of the channel of the receptor?
Non-competitive antagonist