Drug safety, measurements, and tolerance development

Question 1

The therapeutic index equation TD50/ED50 is for ______

Answer 1

Humans

Question 2

What is the definition of Affinity?

Answer 2

The measurement of how well a drug binds

Question 3

What is potency?

Answer 3

The intensity of a drug/measure of the dose required to produce a response

Question 4

What is the measurement of how well a drug binds?

Answer 4

Affinity

Question 5

The therapeutic index equation LD50/ED50 is for ______

Answer 5

Animals

Question 6

What is the BMAX of a drug?

Answer 6

The maximum receptor population

Question 7

What values of the therapeutic index is considered safe?

Answer 7

Over 100

Question 8

What is the Therapeutic index equation for animals?

Answer 8

LD50/ED50

Question 9

A therapeutic index value below 10 is considered ______

Answer 9

Dangerous

Question 10

A therapeutic index value above 100 is considered ______

Answer 10

Safe

Question 11

What is the Therapeutic index equation for humans?

Answer 11

TD50/ED50

Question 12

What is efficacy?

Answer 12

The measure of how well a drug works as intended

Question 13

What values of the therapeutic index is considered dangerous?

Answer 13

Under 10

Question 14

What is the measure of how well a drug works as intended?

Answer 14

Efficacy

Question 15

What is the measure of the intensity of a drug?

Answer 15

Potency

Question 16

What is the state where all receptors have been bound/the threshold for maximal response to occur?

Answer 16

Saturation

Question 17

What is the definition of Saturation?

Answer 17

The point where all receptors have been bound/ the threshold for maximal response to occur

Question 18

What is the maximum receptor population of a drug?

Answer 18

BMAX

Question 19

Lower KD50 = Higher ______

Answer 19

Affinity