Drugs in pregnancy Flashcards
What are some fetal abnormalities caused by smoking?
Low birth weight
Preterm birth
Cerebral palsy
Learning difficulties
What kind of antihypertensive drugs are teratogenic?
ACE inhibitors
ARBs
Which anti-hypertensives are preferred in pregnancy?
Labetolol
Nifedipine
Methyldopa
Hydralazine
How does pregnancy affect epilepsy drug metabolism?
Changes free serum concentration of antiepileptics
What are the safest anti-epileptic drugs for pregnant mothers?
Carbamazepine
Lamotrigine
What kind of malformations may the anti-epileptic drug phenobarbitone cause?
Cardiac
What effect may sodium valproate have on pergnancy?
Neural tube defect (NTD)
Facial clefts
What should always be given alongside anti-epileptics in pregnancy?
High dose folic acid
Can metformin be given for gestational or t2 diabetes in pregnancy?
Yes
Which drug should be avoided when combatting thromboembolism?
Warfarin
What is the drug of choice for thromboembolism in pregnancy?
LMWH
Which asthma drug can potentially cause toxicity?
Theophylline
Is risk of medication higher or lower than risk of untreated asthma in pregnancy?
Lower
Should ibuprofen be avoided in pregnancy?
In 3rd term yes
Do morphine base drugs cause an increased risk of congenital abnormalities?
No
What is a risk associated with using morphine based drugs in pregnancy?
Neonatal respiratory depression and withdrawal
Why is lithium avoided during pregnancy?
Ebsteins’s anomaly
Cardiac anomaly
Why is diazepam avoided during pregnancy?
Cleft lips/palate
Floppy infant syndrome
Why is quetiapine avoided in pregnancy?
Large baby
Poor neonatal adaptation syndrome
Why is tetracycline avoided in pregnancy?
Effects on skeletal development
Discolouration of teeth
Why are sulfonamides avoided during pregnancy?
Folate antagonist
Teratogenic
What are some potential damages caused by aminoglycosides during pregnancy?
Auditory or vestibular nerve damage
