Drugs in Heme Malignancies Flashcards
1
Q
What governs design of chemo combo treatment regimens?
A
Toxicity of “classical” anticancer agents
2
Q
What is the basic outline of how chemo combo regimens work?
A
HIGH dose (very toxic; induction therapy) followed
by LOWER dose (less toxic; consolidation therapy)
– Drugs used alone or accompanied by adjunctive
radiotherapy
3
Q
What governing guidelines must chemo combos follow?
A
Drug MUST show activity against tumor type
– No two drugs should have the same mechanism of action
– Drugs should have different patterns of dose-limiting
toxicity
4
Q
APL drugs?
A
arsenic trioxide and ATRA
