AML Risk Status

Question 1

The three “risk” categories associated with AML include:

Answer 1

Better risk
intermediate risk
Poor-risk

Question 2

What cytogenetic findings would suggest better risk AML?

Answer 2

inv(16)
t(8,21)
t(15,17)

Question 3

What cytogenetic findings would suggest intermediate risk AML?

Answer 3

normal cytogenetics
+8 alone
t(9,11)
other non-defined

Question 4

What cytogenetic findings would suggest poor risk AML?

Answer 4

complex karyotypes
monosomal karyotypes
-5,-5q,-7, -7q
11q23- non t(9,11)
inv(3)
t(6,9)
t(9,22)

Question 5

What molecular abnormalities would suggest better risk AML?

Answer 5

Normal cytogenetics: NPM1 mutation in the absence of FTL3-ITD or isolated biallelic CEBPA mutation

Question 6

What molecular abnormalities would suggest intermediate risk AML?

Answer 6

t(8,21), inv(16), with c-KIT mutation

Question 7

What molecular abnormalities would suggest poor risk AML?

Answer 7

Normal cytogenetics with FLT3-ITD mutation

Question 8

How would a high sick patient be treated?

Answer 8

allogeneic SCT

Question 9

How would an intermediate/low risk patient be treated?

Answer 9

chemo alone