Drugs in health and disease

Question 1

First generation antipsychotic drugs mechanism

Answer 1

Blocks dopaminergic receptors (D2)
- Non-selectively

Can also have cholingeric, alpha-adrenergic, histaminergic and serotonergic effects

Question 2

First generation antipsychotic drug examples

Answer 2

Chlorpromazine

Levomepromazine

Promazine

Haloperidol

Question 3

Effects from blocking dopaminergic receptors

Answer 3

Hyperprolactinaemia

Sexual dysfunction

Sedation (by decreasing arousal)

Side effects

• Extrapyramidal symptoms
• Parkinsonism: tremors, bradykinesia, muscle rigidity
• Tardive dyskinesea
• Increase in appetite due to loss of inhibition
• Acute dystonia
• Akathisia

Question 4

Effects of blocking cholinergic receptors

Answer 4

Symptoms

• Dry mouth
• Constipation
• Micturition dysfunction
• Blurred vision

Question 5

Effects of blocking alpha adrenergic receptors

Answer 5

Nasal congestion

Erection and ejaculation problems

Question 6

Effects of blocking histamine receptors

Answer 6

Drowsiness

Question 7

Effects of blocking serotonergic receptors

Answer 7

Hypotension

Temperature dysregulation