Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

308 Clinical pharmacology > Drugs in health and disease 1 > Flashcards

Drugs in health and disease 1 Flashcards

1
Q

What are the characteristics of chlorpromazine hydrochloride?

A

White / almost white crystalline powder
Very soluble in water and freely soluble in alcohol
Decomposes on exposure to air and light
Melts at 196 degrees C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What short term uses do antipsychotic drugs have?

A

Calm disturbed patients with underlying psychopathology

Severe anxiety

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Give examples of group 1 phenothiazine derivatives

A

Chlorpromazine hydrochloride
Levomepromazine
Promazine hydrochloride

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Give an example of group 2 phenothiazine derivatives

A

Periciazine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Give examples of group 3 phenothiazine derivatives

A

Fluphenazine decanoate
Perphenazine
Prochlorperazine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What type of phenothiazine derivatives have the most pronounced sedative effects?

A

Group 1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What type of phenothiazine derivates have the least pronounced sedative effects?

A

Group 3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What type of phenothiazine derivates have the most extrapyramidal side effects?

A

Group 3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What type of phenothiazine derivates have the least EPS?

A

Group 2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are the indications for chlorpromazine hydrochloride?

A 
Schizophrenia and pyschoses
Mania
Short-term adjunct for severe anxiety
Psychomotor agitation, excitement or violence
Intractable hiccup
Nausea and vomiting
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the effect of blocking dopamine D2 receptor?

A

Extrapyramidal side effects

Increased prolactin concentraion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the effect of blocking cholinergic receptor?

A

Antimuscarinic symptoms (dry mouth, constipation, difficulty with micturition, blurred vision)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the effect of blocking alpha adrenergic receptor?

A

Nasal congestion

Erection and ejaculation problems

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is the effect of blocking histaminergic receptors?

A

Drowsiness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the effect of blocking serotonergic receptor?

A

Hypotension

Interference with temperature regulation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are the symptoms of hyperprolactinaemia?

A 
Sexual dysfunction
Reduced bone mineral density
Menstrual disturbance
Breast enlargement
Galactorrhoea
17
Q

What cardiovascular side effects can antipsychotics cause?

A

Tachycardia
Arrhythmias
Hypotension

18
Q

What are the signs of neuroleptic malignant syndrome?

A

Hyperthermia
Fluctuating consciousness levels
Muscle rigidity
Autonomic dysfunction

308 Clinical pharmacology (10 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions